1. BIPN 148 Lecture 16

2. Remembering Jennifer Anniston

3. Activate Visual and Auditory Neurons

4. Stimulate Hippocampal Neurons

5. Visual Somatosensory Olfactory Auditory Perirhinal Cortex Entorhinal Cortex Dentate Gyrus CA3 CA1 Sensory Regions Of Cortex Perirhinal/ Entorhinal Cortex Hippocampal Formation Get info from cortex to hippocampus

7. Stimulate hippocampal synapses

8. Activate Spines

12. Potentiate Synapses

16. Activate CaMKII

17. Phosphorylate AMPA receptors

18. Phosphorylate GluR1on S831

19. Insert GluR1 at synapses

20. Unsilence synapses

21. Use Stargazin to traffic AMPA-R Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.

22. Induce gene expression

23. Use CaMKIV to induce gene expression

24. CRESRE zif268 C/EBP krox20 AMPAR HOMER BDNF NT-3 Arc CBP/CREB CaMKIV + ERK Elk-1 RSK2 Express new genes

25. New gene products or proteins Signal to nucleus New gene products or proteins Synaptic Potentiation Locally generated tag captures new gene product Synaptic tag NMDAR Send gene products to synapse

26. Remembering Jennifer Anniston Activate visual & auditory neurons Stimulate hippocampal neurons Change synaptic strength by inserting AMPA receptors Induce gene expression Stabilize change in synaptic strength Recall image with visual cue Don’t confuse with Angelina Jolie