1. Thymus and Spleen Dr. Raid Jastania Dec 2006

2. By the end of this session you should know the clinical and pathological features of –Thymic hyperplasia –Thymoma List the causes of splenomagaly

3. Thymus Hyperplasia –Usually asymptomatic, incidental or associated with Myasthenia Gragis –Other autoimmune diseases: SLE, Rheumatoid –Pathology: enlargement of the thymus with lymphoid follicles with germinal centers

5. Thymus Thymoma: –Epithelial neoplasm of the thymus –Types: Benign Malignant type1: invasive thymoma Malignant type2: thymic carcinoma –Clinical: Mass lesion –Pathology: enlarged thymus, lobulated mass with fibrous septation. Epithelial tumor mixed with lymphoid cells. (cortical, medullary)

11. Spleen What are the causes of splenomegaly?

12. List of Causes Primary vs Secondary Congenital/Genetic vs Acquired The Acquired: Non-neoplastic, Neoplastic Non-neoplastic: Inflammatory, Idiopathic Inflammatory: Infection, Drugs, Toxins, Metabolic, Immune

13. Congestion

14. Large cell lymphoma

15. CLL

16. Angiosarcoma

17. Gaucher Disease

18. Spleen What are the features of hypersplenism?

19. Symptoms and Signs Primary, Secondary, Non specific Anatomical and Functional Complications of the disease process

20. By the end of this session you should know the clinical and pathological features of –Thymic hyperplasia –Thymoma List the causes of splenomagaly