1. A Look Back at the Past Year Genomics in Nature Patience Tenney

2. Themes  new sequenced genomes  functional genomics  evolution  techniques  future?

3. Sequenced  Human chromosome 14  2 immune loci, 60 disease genes  Human Y chromosome  MSY region  Neurospora crassa (bread mould)  3 new yeast species: Saccharomyces paradoxus, S. bayanus, and S. mikata  comparison study with S. cerevisiae

4. Functional  duplicated genes purpose is for stability  RIP mechanism in N. crassa  alternate recombination mechanism in Y chromosome  Coprinus cinereus (ink cap mushroom) apoptosis signal  cell differentiation regulation and reprogramming

5. evolution  Bacillus antracis pathogenicity  ancestor a parasite of saprophyte  short and full viral genomes work in mutually beneficial relationship  paired genomes compliment out defects in individual  short genome has useful trait for larger genome to increase pathogenicity

6. Techniques  genome wide genetic analysis of gene expression  whole genome shotgun strategy  comparison study  balancer chromosome

7. Future  NHGRI outline of three themes  biology  structure and function of genes  regulation  Health  developing improved medications and techniques  Society  maximize benefits while minimizing harm

8. Future?