1. Non-coding RNAs (ncRNAs)

2. Non-coding RNAs (ncRNAs)

3. Non-coding RNAs (ncRNAs)
*Small Regulatory RNAs
*Infrastuctural RNAs
*Micro-, Small-interfering RNAs
*Long Non-coding RNAs
Mattick 2009

4. Review: X inactivation
Mechanism of inactivation:
XIC or X-inactivation center
Avner, P. and Heard, E. 2001

5. *Part of a larger complex
Mechanisms of Action
*Direct base-pairing
*Molecular mimicry
*Part of a larger complex

6. Processing and Activity of Naturally Occurring miRNA

7. Pathways to Gene Silencing by miRNA

8. Example: lin-4 http://microrna.ic.cz/obr/image001.png