1. Lecture 8 Elementorganic Toxins

2. Determination Graphite furnace atomic absorption Cold Vapor Atomic absorption and Fluorescence ICP-MS HPLC-ICP-MS GC-MS GC-ECD

4. Electrodeless Discharge Lamps Sn, Cd, Hg, Zn, Pb, As, Sb, Bi, Tl, In Se, Te, Rb, and Cs

6. +KMnO 4 +NH 3 OH + To convert organic mercury into Hg 2+ To remove MnO 4 - ion: To MHS-15 30 min Overnight 0.1-0.3g HNO 3 @85 o C Digestion Procedure: Sample

7. To cuvette N2N2 SnCl 2 Sample compartment PerkinElmer MHS-15 Mercury Analyzer

8. Hollow cathode Hg lamp Hg vapor Monochromator Detector Data processing Quarz cuvette 253.6 nm Thermo Jarrel Ash Smith-Hieftje 11 AAS

10. ECD detector

11. ICP detector

12. sarin Malathion Malaoxon warfare agent Organophosphorus Pesticides GC

13. 30. fenthion 31. aspon 32. parathion-ethyl 33. chlorpyrifos 34. trichloronate 35. chlorfenvinphos 36. merphos 37. crotoxyphos 38. stirofos 39. tokuthion 40. merphos oxidation product 41. fensulfothion 42. famphur 43. ethion 44. bolstar 45. carbophenothion 46. triphenyl phosphate (IS) 47. phosmet 48. EPN 49. azinphos-methyl 50. leptophos 51. tri-o-cresyl phosphate 52. azinphos-ethyl 53. coumaphos 2. hexamethylphosphoramide 3. mevinphos 4. trichlorfon 5. TEPP 6. thionazin (IS) 7. demeton-O 8. ethoprop 9. tributyl phosphate (SS) 10. dicrotophos 11. monocrotophos 12. naled 13. sulfotepp 14. phorate 15. dimethoate 16. demeton-S 17. dioxathion 18. terbufos 19. fonophos 20. phosphamidon isomer 21. diazinon 22. disulfoton 23. phosphamidon 24. dichlorofenthion 25. parathion-methyl 26. chlorpyrifos methyl 27. ronnel 28. fenitrothion 29. malathion Organophosphorus Pesticides Oven temp.: 100°C to 180°C @ 10°C/min. (hold 2 min.), to 300°C @ 18°C/min. Inj. / det. temp.: 250°C / 280°C FPD Solvent: hexane

14. 2,4-Dichlorophenoxyacetic acid (2,4-D) 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) 1. 1,4,7,8-TCDD 2. 2,3,7,8-TCDD 3. 1,2,3,4-TCDD 4. 1,2,3,7 5. 1,2,3,8-TCDD 6. 1,2,7,8-TCDD GC: 2.0μL splitless injection of TCDD isomers, approximately 0.5ng each isomer Splitless hold: 0.45 min ECD detector