1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Chapter 23, part A Microbial Diseases of the Cardiovascular and Lymphatic Systems

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Cardiovascular System and Lymphatics System Blood—Transports nutrients to and wastes from cells WBCs—Defend against infection Lymphatics—Transport interstitial fluid to blood Lymph nodes—Contain fixed macrophages

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Cardiovascular System Figure 23.1

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Lymphatic System Figure 23.2

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Sepsis Bacteria growing in the blood Severe sepsis Decrease in blood pressure Septic shock Low blood pressure cannot be controlled Sepsis and Septic Shock Figure 23.3

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gram-negative Sepsis Endotoxins caused blood pressure decrease Antibiotics can worsen condition by killing bacteria Gram-Positive Sepsis Nosocomial infections Staphylococcus aureus Streptococcus pyogenes Group B streptococcus Enterococcus faecium and E. faecalis Sepsis

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Puerperal Sepsis (Childbirth fever) Streptococcus pyogenes Transmitted to mother during childbirth by attending physicians & midwives Sepsis

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Endocarditis Inflammation of the endocardium Subacute bacterial endocarditis Alpha-hemolytic streptococci from mouth Acute bacterial endocarditis Staphylococcus aureus from mouth Pericarditis Streptococci Bacterial Infections of the Heart

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Bacterial Infections of the Heart Fgirue 23.4

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Inflammation of heart values Autoimmune complication of Streptococcus pyogenes infections Rheumatic Fever Figure 23.5

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Francisella tularensis, gram-negative rod Transmitted from rabbits and deer by deer flies Bacteria reproduce in phagocytes Tularemia

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Tularemia Figure 23.6

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Brucella, gram-negative rods that grow in phagocytes B. abortus (elk, bison, cows) B. suis (swine) B. melitensis (goats, sheep, camels) Undulating fever that spikes to 40°C each evening Transmitted via milk from infected animals or contact with infected animals Brucellosis (Undulant Fever)

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Bacillus anthracis, gram-positive, endospore-forming aerobic rod Found in soil Cattle are routinely vaccinated Treated with ciprofloxacin or doxycycline Cutaneous anthrax Endospores enter through minor cut 20% mortality Anthrax

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gastrointestinal anthrax Ingestion of undercooked food contaminated food 50% mortality Inhalational anthrax Inhalation of endospores 100% mortality Anthrax Figure 23.7