1. The role of who in leg imaginal disc morphogenesis

2. The Drosophila who gene has pleiotropic functions during metamorphosis who (wings-held-out) also named how, struthio, qkr93F Encodes KH RNA binding protein Strong similarity to nematode GLD-1 and mouse QK1 Required for tendon cell differentiation in embryos who mutants exhibit defects in muscle, muscle attachment, wing development and adult leg development

3. who mutants show multiple lethal phases

4. who is expressed during metamorphosis

5. who mutants show defects in leg development

6. who Stubble control

12. Conclusions who mutants show multiple lethal phases and pleiotropic effects during metamorphosis. who is expressed during metamorphosis. who mutant leg discs undergo proper cell shape changes during morphogenesis but do not extend fully at the prepupal-pupal transition. This defect is associated with inappropriate orientation of leg imaginal discs. The pleiotropic function of who suggests that KH proteins play essential roles in development of numerous cell types.

13. Acknowledgments Mount Holyoke College Tina Fortier Craig Woodard University of Maryland Biotechnology Institute Runa Chatterjee Susan Klinedinst Eric Baehrecke