1. First Lecture Gihan E-H Gawish, MSc, PhD Ass. Professor Molecular Genetics and Clinical Biochemistry Molecular Genetics and Clinical BiochemistryKSU

2. What is the molecular biology science? And Why it is important to study?!

3. Timeline Events of Molecular Biology: 1860Mendel – Mendel’s law of inheritance, gene& chromosome 1868Miescher – nuclein, contained an acidic material 1890Weismann - substance in the cell nuclei controls development. 1900Chromosomes shown to contain hereditary information, later shown to be composed of protein & nucleic acids. 1928Griffith’s Transformation Experiment 1944Avery’s Transformation Experiment 1953Hershey-Chase Bacteriophage Experiment 1953Watson & Crick propose double-helix model of DNA 1956Gierer & Schramm/Fraenkel-Conrat & Singer Demonstrate RNA is viral genetic material.

4.  The law of independent assortment  The law of independent segregation  The law of dominance Comment: Genes are located on chromosomes

5.  Called in nuclein since it was from the nucleus  Had large amounts of phosphorous and no sulfur so was very different than protein Comment: the two constituents of chromosomes; Proteins & DNA Analytical Tests for C, H,P,O and N “Nuclein”

6. DNA the molecule of life