1. Surgical Complications Rajan Thakkar

2. Surgical Complications Wound Thermal Regulation Postoperative Fever Pulmonary Cardiac Renal Gastrointestinal Metabolic Neurological

3. Surgical Complications Primary disease Operation Unrelated factors Complications leading to other complications Prevention

4. Wound Complications Dehiscence Seroma Hematoma Infection Incisional Hernia

5. Wound Dehiscence Separation of facial layers Serosanguinous drainage Technical Complication Risk Factors Mortality approaches 30% Evisceration

7. Incisional Hernia

8. Seroma Collection of liquefied fat, serum and lymphatic fluid under the incision Benign No erythema or tenderness Mastectomy, axillary and groin dissections Treatment

9. Hematoma Abnormal collection of blood – Discoloration of the wound edges (purple/blue) – Blood leaks through skin sutures Imperfect hemostasis Potential for secondary infection Neck hematomas can be dangerous

10. Wound Infection Major problem Superficial Deep Organ space Most commonly occur 4-6 days post-op Erythema, tender, edema 2.5% of abdominal incisions Staphylococcus aureus

11. Wound Infection Necrotizing fasciitis – Bacterial infection of underlying fascia – Classically Streptococcus, most often polymicrobial with anaerobes/GNR – Surgical debridement and IV antibiotics Clostridial Myosistis – Clostridial muscle infection (myonecrosis and gas gangrene) – Clostridium perfringens – Surgical debridement and IV antibiotics

12. Necrotizing fasciitis

14. Necrotizing Fasciitis

15. Complications of Thermal Regulation Hypothermia Malignant Hyperthermia

16. Hypothermia Drop in body temperature of 2 degrees C Causes Body’s Response Temperature below 35 C – Coagulopathic – Platelet dysfunction Mild - 32 – 35C = 90-95F Mod – 28 – 32C = 82–90F Severe – 25 – 28C = 77-82F Extreme

17. Malignant Hyperthermia Rare; autosomal dominant Fever, tachycardia, rigidity, cyanosis First sign is increased end tidal CO2 Often within 30 minutes Treatment: Dantrolene, correct electrolytes, cooling blanket

18. Postoperative Fever The Six W’s – Wind: pneumonia – Wound: infections – Water: UTI – Walking: DVT (possible PE) – Waste: abscess – Wonder Drug: medication Noninfectious – Within the first 48-72 hours Infectious – Fevers POD 3-8 – Standard work up includes Blood cultures UA and Urine Cultures CXR Sputum cultures Tylenol/Motrin

19. Pulmonary Complications Atelectasis – Peripheral alveolar collapse due to shallow tidal breaths – Most common cause of fever within 48 hours of surgery – Incentive spirometry Aspiration Pneumonitis – Reduced by pre-op fasting, protonix, cricoid pressure Nosocomial Pneumonia Pulmonary edema – CHF – ARDS Pulmonary embolus – 500,000 per year – 1 in 5 are fatal – Prevention

20. Pulmonary Embolus

21. ARDS

22. Cardiac complications Hypertension Ischemia/Infarction – Leading cause of death in any surgical patient – Key to treatment: prevention – MONA Arrhythmias – >30 seconds of abnormal cardiac activity – Key to treatment is to correct underlying medical condition

23. Renal Complications Urinary retention – Inability to evacuate a urine-filled bladder – Commonly a reversible abnormality – Perianal and Hernia repairs Acute Renal Failure – Pre-renal – Intrinsic – Post-renal

24. Gastrointestinal Complications Postoperative ileus GI Bleeding Pseudomembranous colitis Ischemic Colitis Anastomotic Leak Enterocutaneous fistula

25. Postoperative Ileus Lack of function without definitive obstruction Prolonged by extensive operative manipulation, SB injury, narcotic use, abscess and pancreatitis Must be distinguished from SBO Flat and Upright abdominal film – Ileus: dilated bowel throughout, air in colon and rectum – SBO: air fluid levels, no colonic or rectal air

26. ILEUS

27. SBO

28. Gastrointestinal Complications GI Bleeding – From Any source (get a detailed history) – Gastric “stress” ulcers (Curling’s Ulcer) Uncommon with invention of H2Blockers and PPIs Pseudomembranous colitis – Superinfection with C difficile – Alteration of intestinal flora by perioperative antibiotics – Toxic colitis is a surgical emergency (mortality of 20-30%) Ischemic Colitis – Bowel affected helps determine cause – Surgical devascularization, hypercoagulable states, hypovolemia and emboli Anastomotic leak Enterocutaneous fistula – The most complex and challenging surgical complication

29. C diff colitis

31. Anastomotic leak in GBP

32. Metabolic Complications Adrenal Insufficiency – Uncommon but potentially lethal – Sudden cardiovascular collapse Hypotension, fever, confusion, abdominal pain – “Stim” test, administration of hydrocortisone Baseline serum cortisol, 30 min, 60 min Hyper/Hypothyroidism SIADH – Continued ADH secretion despite hyponatremia – Neurosurgical procedures, trauma stroke, drugs (ACE- I, NSAIDs)

33. Neurologic Complications Beware the drugs you will be prescribing Delirium, Dementia and Psychosis Seizure Disorders Stroke and Transient Ischemic Attacks