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Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides.

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Presentation on theme: "Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides."— Presentation transcript:

1 Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides

2 Glycosidic Linkage

3 Disaccharides maltose cellobiose lactose sucrose  -D-glucosyl-(1->4)-  -D-glucopyranose)  -D-glucosyl-(1->4)-  -D-glucopyranose)  -D-galactosyl-(1->4)-  -D-glucopyranose)  -D-glucosyl-(1->2)-  -D-fructofuranose)

4 Higher Oligosaccharides

5 Oligosaccharide groups are incorporated in to many drug structures

6 Polysaccharides

7 Amylose and Amylopectin

8 Iodine binding to starch

9 glycogen

10 Dextrans

11 Cellulose

12 Cellulose vs Amylose Glucose units rotated 180 o relative to next residue cellulose amylose

13 Cellulose

14 Chitin

15 Chitin vs Cellulose

16 Glycoproteins

17 O-linked Glycoproteins

18 Blood ABO Antigens Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)

19 N-linked Glycoproteins


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