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Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides
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Glycosidic Linkage
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Disaccharides maltose cellobiose lactose sucrose -D-glucosyl-(1->4)- -D-glucopyranose) -D-glucosyl-(1->4)- -D-glucopyranose) -D-galactosyl-(1->4)- -D-glucopyranose) -D-glucosyl-(1->2)- -D-fructofuranose)
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Higher Oligosaccharides
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Oligosaccharide groups are incorporated in to many drug structures
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Polysaccharides
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Amylose and Amylopectin
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Iodine binding to starch
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glycogen
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Dextrans
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Cellulose
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Cellulose vs Amylose Glucose units rotated 180 o relative to next residue cellulose amylose
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Cellulose
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Chitin
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Chitin vs Cellulose
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Glycoproteins
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O-linked Glycoproteins
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Blood ABO Antigens Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)
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N-linked Glycoproteins
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