1. 結構生物學期中報告 M93360001 洪國勝

2. Structure and Mechanism of the Lactose Permease of Escherichia coli Science Agust 2003 VOL 301 P610-615 Jeff Abramson, Irina Smirnova, Vladimir Kasho, Gillian Verner, H. Ronald Kaback, So lwata Department of Biological Science, Imperial College London PDB ID :1PV6 IPV7

3. Escherichia coli Lactose Permease (LacY) is a particularly well-studied representative of the first subset of membrane transport proteinsand a member of the oligosaccharide/proton symport subfamily of the MFS transporters. For advandage research of LacY, the author used X-ray structure of the inward-facing confomation of LacY to discuss LacY biofunction and mechanism of suger/proton symport.

4. cytoplasm Plasm membrane Proton H + lactose Lac Y Lac Y transform lactose with proton as “Symport”

5. Structure Of Lac Y 1PV6

6. Structure Of Lac Y+TDG 1PV7

7. Structure analysis 1.Suger bindsing 2.Proton interaction sites 3.Input/release mechanism