1. The Nature of IT IS6800 Professional MBA Course Rick Morgan David Ouellette Paul Hippenmeyer 8 October 2004

2. Key Products

4. Pfizer Company Background World’s largest pharmaceutical company –$45.2 Billion in Revenue (2003) –Headquarters New York, NY 122,000 employees $236 Billion market cap

5. Selected Financials: 2003 Source: 2003 Financial Report REVENUES: $45.2 Billion R&D Budget:$7.1 Billion Net Income:$3.9 Billion % of revenues8.7%

6. Revenue by Business Segment 87.7% 3.5% 6.7%

7. David Ouellette

8. Pharmaceutical Division Pfizer Global Research and Development (PGRD) –Drug Discovery thru Clinical Trials Pfizer Global Manufacturing Pfizer Global Pharmaceuticals –Marketing, Strategic Planning, Sales

9. Pfizer Global Research & Development (PGRD) 10 Research sites –Amboise, France –Sandwich, UK –Nagoya and Tokyo, Japan –USA … Cambridge, Groton/New London, La Jolla, Ann Arbor, Kalamazoo, and St. Louis

10. Discovery Research Informatics (DRI) PGRD IT Organization Informatics (PGRDi) Corporate Information Technology (CIT) Clinical Regulatory Informatics (CRI) Development Sciences Informatics (DSI) Enterprise Informatics (EI) Applications Network and Infrastructure

11. Informatics (PGRDi) Corporate Information Technology (CIT) PGRD IT Organization PGRD Leadership Team Corporate Leadership Team Head of FinanceCFO

12. IT Budget Estimates $45.2B $40.0B $7.1B 5% $2.3B >>$1B 88%

13. PGRD IT Budget Issues Software licenses are huge drain on budget Too many applications to support. All capital request are funneled to Groton (PGRD headquarters) –No local control

14. Paul Hippenmeyer

15. PGRD Governance Model Discovery Leads Safety Science Leads Pharm. Sci. Leads PDM Leads PGRDi Board of Directors (oversight) Discovery Unit IT Governance Board Safety Sciences Unit IT Governance Board Pharmaceutical Sciences Unit IT Governance Board PDM Unit IT Governance Board Business Unit Governance Decision-making authority within business unit

16. Vendor Sourcing Most PGRD application development in- house –Occasionally one vendor chosen Temporary staff hired on an “as needed” basis

17. Evaluating Cyclone Commerce E2BM (Enterprise eBusiness Management) Safety reporting of Severe Adverse Events (SAEs) –Speed Clinical Trial and Regulatory submissions –Compliance with various regulatory agencies and ICH guideline

18. Pharmaceutical Business

19. Multinational Safety Organization Collecting Data from 50+ countries 150,000 reports per year

20. SAE Reporting

21. Clinical Trial Management and Submission

22. Summary PGRD IT Separate reporting lines for applications vs. network and architecture Little out-sourcing of PGRD application development Software licensing huge drain on budget Shear number of applications limits resources Moving toward centralized type governance

23. IT Organizational Mapping Pfizer IT organization resembles a “Platform Model” “Primarily aims to insure that IT function provides assets, services and resources for business innovation across the enterprise” (Agarwal and Sambamurthy, MIS Quarterly Executive 1 (1), p. 9, (2002) Corporate IT seen as enterprise-wide resource for architecture and networks Business units own IT innovation with unique application needs.

24. Pfizer IT Governance Mapping Within PRGDi the governance appears to be transitioning from a “Duopoly Model” to a “Federal Model” of governance (Weill, MIS Quarterly Executive, 3(1), (2004). Currently independent Business Units All business units represented Enterprise-wide network and architecture input Ultimately C-level executive committee involvement

25. Sources Email Correspondence and phone interview (10/4/2004) with Jeffrey Gaw, Director, Scientific Informatics, Pfizer Global Research and Development Pfizer 2003 Financial Report Presentation by Pfizer and Cyclone Commerce on Electronic Submissions and Safety Tracking (11/2003) James Champy, “Re-Examining the Infrastructure”, Optimize Magazine, September, 2003.

26. “The ultimate discussion is about value to the business. If we understand true life-cycle costs and benefits, we can evaluate any decision on its economic value to the business. That being said, not all potential investments can be made on an ROI basis. Some have to be made for risk-mitigation or regulatory reasons. Others are option-creating investments that are experimental in nature. By far, however, the vast majority of decisions by an infrastructure manager or CIO will be made on the basis of return. Understanding costs and benefits makes that possible.” -Chuck Williams. CTO, Pfizer

27. BACKUPS