1. Emotion, Feelings and Motivation

2. Stimulus Brain Pleasure Stress Brain Depression Periphery

3. The particular emotion experienced is a function of cross- talk between neocortical and subcortical structures, as well as feedback from peripheral receptors. Stimulus Susan Iversen; Irving Kupfermann; Eric R. Kandel

4. Whether conscious feeling follows bodily changes (James-Lange) or bodily changes follow feeling ?

5. Emotion & Feeling An emotional state has two components, one evident in a characteristic physical sensation and the other as a conscious feeling “Emotion” sometimes is used to refer only to the bodily state (ie, the emotional state) and “feeling” is used to refer to conscious sensation When frightened we not only feel afraid but also experience increased heart rate and respiration, dryness of the mouth, tense muscles, and sweaty palms

6. James-Lange Theory (1880s) James wrote: “We feel sorry because we cry, angry because we strike, afraid because we tremble.”

7. Epinephrine’s effects Not Informed How nervous are you? EpinephrineSaline Group 3Group 4

8. Patients in whom the spinal cord has been accidentally severed appear to experience a reduction in the intensity of their emotions.

9. Cannon's study of peripheral responses to intense emotion fight-or-flight response (1920) the physiological responses to emotionally significant stimuli are too undifferentiated to convey to the cortex specific, detailed information about the nature of an emotional event.

10. Bard’s Experiments (1920s) Sham rage: animals with the whole cerebral cortex removed retain fully integrated emotional responses

11. Cnnon-Bard Theory The Hypothalamus mediating both the cognitive and peripheral aspects of emotion

12. By progressive transections the coordinated response disappeared when the hypothalamus was included in the ablation

13. Schachter- Singer

14. Epinephrine’s effects Informed Epinephrine’s effects Not Informed How nervous are you? Epinephrine Saline Group 1Group 2Group 3Group 4 Schachter’s Cognitive Experiment (1960s)

15. James-LangeCannon-BardSchachter Peripheral stimuli Peripheral stimuli Emotional state: autonomic, endocrine, skeletomotor responses Conscious feelings Peripheral stimuli Hypothalamus Emotional state: autonomic, endocrine, skeletomotor responses Memories in amygdala Conscious feelings & emtional state Neuroanatomy Memory has two major forms: a conscious (explicit) memory for facts and personal events and an unconscious (implicit) memory for motor and sensory experiences. Central or Peripheral sti Cognitive translation

16. When the sound alone is given, it evokes physiological changes in blood pressure and freezing similar to those evoked by the sound and shock together (right)

17. The Hypothalamus Coordinates the Peripheral Expression of Emotional States In anesthetized animals, Ranson (1932) evoked individual conceivable autonomic reaction by stimulating different regions of the hypothalamus In 1940s, Walter Hess extended Ranson's approach to awake, unanesthetized cats and found that different parts of the hypothalamus produce characteristic constellations of reactions

18. Fear and Amygdala Electrical stimulation of the amygdala in humans produces feelings of fear and apprehension. Urbach-Wiethe disease disrupts the unconscious processing: The patients fail to learn the cues that normal subjects use to discern fear in facial expressions, but they can accurately identify familiar people from photographs.

19. Fear and Amygdala When subjects were asked to view photographs of fearful or happy faces, the PET responses in the amygdala were significantly greater to fearful expressions than to happy expressions. The response in the left amygdala increases with increasing fearfulness and decreases with increasing happiness

20. Fear and Amygdala Bilateral lesions of the basolateral complex of the amygdala in experimental animals abolish this learned response to fear. Patients with damage to the amygdala do not learn to fear the neutral sound even though most were consciously aware that the neutral sound and the offensive noise were paired together.

21. The Amygdala also mediates the cognitive experience of emotion, particularly in fear.

22. Stimuli from the cortex Electrical stimulation of the orbitofrontal cortex produces many autonomic responses. Lesions of the orbitofrontal cortex reduce the normal aggressiveness and emotional responsiveness of primates, and lesioned animals sometimes fail to show anger when they do not receive expected rewards in a training task.

23. Egas Moniz performed the first prefrontal lobotomy in humans in 1935.(1949 Nobel Prize)

24. Stimuli from the cortex In 1935 John Fulton and Carlyle Jacobsen first reported that removing the frontal cortex (lobotomy) had a calming effect in chimpanzees. Within a few months of Fulton and Jacobsen's report, Egas Moniz, a Portuguese neuropsychiatrist, performed the first prefrontal lobotomy in humans, isolating the orbital frontal cortex. The patients became tamed.

25. Stimuli from the cortex Cortical mechanisms provide a means by which memory and imagination, not just external stimuli, can evoke emotional feelings and they enable us to use emotional information generally in cognitive processing. Cortical structures also provide the means by which conscious thought can suppress reflex emotional responses. Once we know that a “bear” is only a shadow that looks like a bear, the fear subsides.

26. The Amygdala Mediates the Autonomic Expression

27. β-adrenergic blocker selectively impaired the memory for the emotional story Lawrence Cahill, James McGaugh, and co- workers investigated the effect of propranolol, a β-adrenergic receptor blocker, on the long-term memory of an emotionally arousing short story or a closely matched, but more emotionally neutral, story. The β-adrenergic blocker selectively impaired the memory for the emotional story. The drug did not block the subjects' initial emotional reaction to the story when it was first presented, suggesting that nonspecific effects of the drug on arousal or attention could not account for the result.

28. Mood & Monoamines 1.Long-term use of reserpine may cause depression (1959) 2.Some people got euphoric when treated with iproniazid (1952) 3.Imipramine is an effective antidepressant (1958) A. Reserpine almost irreversibly blocks the uptake (and storage) of norepinephrine and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters B.Iproniazid inhibits synaptic monoamine oxidase C.Imipramine inhibit reuptake of norepinephrine and serotonin

30. Motivation how individuals respond to internal rather than external stimuli. This is the domain of motivation. Motivation is a catch-all term that refers to a variety of neuronal and physiological factors that initiate, sustain, and direct behavior. These internal factors are thought to explain, in part, variation in the behavior of an individual over time.

31. Pleasure Love Hierachical Drive States of Motivations Drive states are characterized by tension and discomfort due to a physiological need followed by relief when the need is satisfied.

32. Physiological Needs Temperature regulation involves integration of autonomic, endocrine, and skeletomotor responses Feeding behavior Is regulated by a variety of mechanisms Drinking is regulated by tissue osmolality and vascular volume

33. Recombinant human leptin 0.01-0.04 mg/kg/day, 18 months Noningestive behavior of all three patients was consistently observed to change from very docile and infantile to assertive and adult-like, within 2 weeks of the onset of leptin treatment, before weight loss occurred. PNAS 2004

35. Motivational States Can Be Regulated by Factors Other Than Tissue Needs

36. Experimental Self-Stimulation of the Brain Reward Pathway The Mesolimbic Dopaminergic Pathways Important for Reinforcement

37. In the presence of the drugs animals self-stimulate with a lower-frequency current that was previously ineffective.