1. Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I 2 R: Imagination to reality

2. I 2 R Knowledge Discovery Dept: INTRODUCTION

3. I2RI2R mission: Advance Infocomm Technology to benefit humanity and create prosperity for S’pore core values: Dedication to excellence, passion for innovation, integrity & respect size: 350 RSEs SERCBMRC IHPC DSI IMRE SIMTECH IME ICES

4. EDB-iDA ICT Cluster Map

5. Next Gen IP End-to-end QoS Mobile Middleware Mobile Adhoc Networks Mobile Sensor Networks Organization I2RI2R Communications & DevicesServices & ApplicationsMedia Processing Human Computer Interaction Media Semantics Infocomm Security E-Service Infrastructure Knowledge Discovery Radio SystemsNetworkingLightwaveEmbedded Systems Digital Wireless Mutimedia Signal Processing Noise Reduction Media Adaptation Mixed Media Mining Natural Language Synergy Pervasive Media Perceptual Human Media Speech & Dialogue Biometrics Cryptography Network security Information security Service Composition Service creation Data-in-Network Connected Home Secure Filesystem/ DBMS Modem Technology Multiple Access Smart Antenna Array Systems Network Design WDM Systems Fibre Technology Terminal Software Defined Radio Transceiver system Antenna Radio Over Fiber UWB Knowledge Extraction Decision Systems Discovery Systems

6. Information Security E-services Infrastructure Knowledge Discovery Services & Applications Knowledge Extraction Data fusion from sensors, knowledge extraction technologies. Applications in functional genomics & gene regulatory networks Decision Systems Data Mining technologies. Applications in clinical data analysis and protein network analysis Discovery Systems Data cleansing, modeling & knowledge management technologies. Applications in immunoinformatics and venominformatics Service Creation Policy-based framework for creating/managing application, storage and network services Data-in-Network High-speed data cache and IPC on optical network Service Composition Tech for consumers to create personalized services from component e- services Connected Home Reference design for an OSGi compliant residential gateway Cryptography Cryptographic techniques for privacy protection, high- speed encryption, group digital signatures and new public key infrastructure Information Security Techniques for privacy protection, peer-to-peer system security and media security Network Security Wireless network security, intrusion detection and technology to trace attackers Secure Filesystem Steganographic and reliable file systems/DBMSs on externally managed platforms

7. Integration Technology (Kleisli) Cleansing & Warehousing (FIMM) MHC-Peptide Binding (PREDICT) Protein Interactions Extraction (PIES) Gene Expression & Medical Record Datamining (PCL) Gene Feature Recognition (Dragon) Venom Informatics 1994 19981996 2000 2002 8 years of bioinformatics R&D in Singapore ISS KRDL LIT/I 2 R GeneticXchange Molecular Connections Biobase History

8. Objectives –Translate inspiration from biological systems into advancement of life and computing sciences –Advance data mining technologies in decision systems for complex problems Direction & Plan To work on practical systems for –data mining –data cleansing –knowledge extraction Applied to –gene regulation –protein interaction –clinical data analysis –ligand-receptor interaction in addition to non-bio areas

9. I 2 R Knowledge Discovery Dept: RECENT ACCOMPLISHMENTS

10. Predict Epitopes, Find Vaccine Targets Vaccines are often the only solution for viral diseases Finding & developing effective vaccine targets (epitopes) is slow and expensive process Develop systems to recognize protein peptides that bind MHC molecules Develop systems to recognize hot spots in viral antigens

11. Recognize Functional Sites, Help Scientists Effective recognition of initiation, control, and termination of biological processes is crucial to speeding up and focusing scientific experiments Data mining of bio seqs to find rules for recognizing & understanding functional sites Dragon’s 10x reduction of TSS recognition false positives

12. Diagnose Leukaemia, Benefit Children Childhood leukaemia is a heterogeneous disease Treatment is based on subtype 3 different tests and 4 different experts are needed for diagnosis  Curable in USA,  fatal in Indonesia A single platform diagnosis based on gene expression Data mining to discover rules that are easy for doctors to understand Cancer Cell, 1:133-143, 2002

13. Understand Proteins, Fight Diseases Understanding function and role of protein needs organised info on interaction pathways Such info are often reported in scientific paper but are seldom found in structured databases Knowledge extraction system to process free text extract protein names extract interactions

14. FANTOM2 Consortium Nature 420, 563-573, 2002 Recent Collaborations/Partners Molecular Connections, India RIKEN, Japan St Jude, USA BioBase, Germany Canberra Hosp., Australia GIS, Singapore

15. I 2 R Knowledge Discovery Dept: PEOPLE

16. 18 full-time staff comprising 9 PhD, 6MSc, and 3BSc Our faculty holds adjunct professorial positions in SANBI, Univ. of Canberra, NUS, and NTU Who will you be working with... Limsoon WongSee-Kiong Ng Jinyan LiVladimir Bajic Vladimir Brusic Other PIs Heads of labs

17. Track Record Journals: 3 chief editorial roles, and 9 editorial board memberships International Conferences (last 5 years): 4 conference chairs, and more than 40 program committee roles, 10 keynote lectures, and dozens of plenary talks Publications (last 5 years): More than 100 in last 5 years, mostly in reputable journals (e.g. Nature, PNAS, Cancer Cell, JACM) and top conferences. Patents (last 5 years): 1 granted and 6 pending Commercialization (last 5 years): 2 international start-ups and one software licensed