1. ADC Change with Pixel Shift Joshua Kim

2. I.Review II.Analysis Procedure III.ADC and Error Calculations IV.Current ADC Variation Results V.Future Work Outline

3. Review Problem: –Some lesions are very difficult to contour –Would like to study lesion pixel variation with translation. –Also: Want good organization of data and fast analysis

4. MatLab: –User defined contours for b=0, 520 and 850. –Record coordinates (indices) of contour –Shift in 8 different directions by N pixels –Create ADC value plots as function of shift to study the pixel variations –Conclude effect of transcription uncertainty Review b = 0b = 520b = 850

5. Analysis Procedure Characterize data sets Update spreadsheet log Perform Analysis, save workspace for future analysis if needed Make contour transcriptions independently (for each b-value scan) Apply shifts in different directions, obtain ADC values as a function of shift

6. ADC and Error Calculations Calculations from paper: Matlab code:

7. Directions for ADC Calculations

8. Patient Mejia, Slice 2

9. ADC Variation with Pixel Shift

10. Patient Mejia, Slice 3

11. ADC Variation with Pixel Shift

12. Future Work Continue with contour transcriptions Analyze remaining data sets (and maintain log files) Study effects relative to erosion/dilation Goal: Create 3D ADC variation maps for a user defined contour (assumes b=0 to b=850 data sets are spatially equal)

13. Future Work