1. Inference of Genealogies for Recombinant SNP Sequences in Populations Yufeng Wu Computer Science and Engineering Department University of Connecticut 110001111111001 000110000001111 Prefix Suffix 110000000001111 Breakpoint Recombination: One of the principle genetic forces shaping sequence variations within species

2. Genealogical History with Recombination 100100 S1 = 00 S2 = 01 S3 = 10 S4 = 10 Mutations S1 = 00 S2 = 01 S3 = 10 S4 = 11 10010011 Recombination Assumption: At most one mutation per site 1 00 1 1 0 1010

3. 3 At which Marginal Tree Did Disease Mutations Occur? Use of inferred genealogical history in mapping complex traits Case Control Possible Disease mutation

4. Research Topics related to Recombination Estimate the level of recombination in genomic regions. Infer the genealogical history with recombination. Mapping causative loci for complex traits using inferred genealogical history Computation of likelihood and estimation of population genetic parameters. Research supported by NSF and UConn Research Foundation. 4