1. http://sensor.neusc.bcm.tmc.edu/David/Book.html Powerpoint slides from “Mechanisms of Memory” Class Web site (should be up next week) http://www.biology.ucsd.edu/classes/bipn148.SP05 Office hours: Aryn Gittis Tues 5:30-6:30; Wed 11-12 Pac Hall 1115 Danny Simpson Mon 11-12 CLICS 2nd Floor

2. Ebbinghaus Results

6. Ebbinghaus Test continued (Further analysis of short and long-term memory) Indicate A-L or M-Z Indicate M/F Physical Activity: H/L (H=3 times a week, > 30 minutes each)

7. Ebbinghaus Test 1 continued Write: Delay=48 h Write down as many of the words you remember from Monday

8. FER GUJ MAW QON NID WAP GOC DOM JIS ZUN Ebbinghaus Test 2 Question: What is the time constant of short term memory?

9. M-Z: Write Delay=0 minutes and write down word list A-L: Write Delay=1 minute and write down word list after waiting one minute

10. FER GUJ MAW QON NID WAP GOC DOM JIS ZUN Score memory test

11. Ivan Pavlov Classical Conditioning

12. Pavlovian Associative Conditioning Conditioned Stimulus Unconditioned Stimulus Conditioned Stimulus Unconditioned Response Conditioned Response

13. Time CS US Delay Conditioning Trace Conditioning Categories of Associative Conditioning

14. Corneal Air Puff Elicits Eyeblink Response Corneal Air Puff Given with Tone Tone Given Alone Elicits Eyeblink Response Eye-Blink Conditioning in Rabbits

15. TRAINING CONTEXTUAL TEST CUED TEST Animal is placed in novel context Hears a tone Receives foot shock Animal is returned to same context Test for freezing behavior Animal is placed in modified context Hears a tone Test for freezing behavior Fear Conditioning

16. Training Cued Contextual Cued-Plus-Contextual Fear Conditioning

17. 0.0 0.2 0.4 0.6 0.8 1.0 LiClNaCl grams blueberry bar Conditioned Taste Aversion DAY 1 DAY 2 1 st Exposure to Food Item 2 nd Exposure to Food Item Injection of LiCl or NaCl Grams Ingested on 2 nd Exposure (LiCl treated group compared to NaCl treated control) A B

18. Neophobia DAY 1 DAY 2 1 st Exposure to Food Item A Grams Ingested (1 st exposure compared to second exposure) B 0.0 0.2 0.4 0.6 0.8 1st intake2nd intake grams blueberry bar 2 nd Exposure to Food Item