1. CH 17 – WBC Morphology

2. Five Types of Leukocytes (WBCs)

3. Granular Leukocytes
Eosinophil
Neutrophil
Basophil

4. Neutrophil 60-70% of all WBC’s Anatomy Physiology 10-12 µm diameter
2-6 nuclear lobes
Fine, pale inconspicuous granules
Physiology
Respond first to bacteria damage by chemotaxis
Phagocytosis
After engulfing pathogen releases several chemicals
lysozyme
strong oxidants
defensins

5. Eosinophil 2-4% of all WBC’s Anatomy 10-12 µm diameter
2 connected nuclear lobes
red/orange large, uniform granules, do not obscure the nucleus
Physiology
exit capillaries, enter tissue fluid
combat parasites
histamine
phagocytize antigen-antibody complexes

6. Basophil 0.5-1% of all WBC’s Anatomy Physiology 8-10 µm diameter
bilobed or irregular nucleus
round, blue-black granules may obscure the nucleus
Physiology
exit capillaries to enter tissue fluid
mature into mast cells
release heparin, histamine, serotonin – stimulate inflammation
Hypersensitivity (allergic) reactions

7. Agranular Leukocytes
Lymphocyte
Monocyte

8. Lymphocytes 20-25% of all WBC’s Anatomy 7-15µm
nucleus large and dark stained, round or indented
cytoplasm forms a pale blue rim around the nucleus

9. Monocytes 3-8% of all WBC’s Anatomy Physiology 14-19 µm
indented or kidney-shaped nucleus (not round)
cytoplasm foamy
Physiology
slower to arrive but survive longer
enlarge, differentiate into fixed and wandering macrophages
remove microbes, cellular debris, following injury

10. End
WBC Morphology
CH 17