1. Exploring the Scientific and Laboratory Animals Industry Lesson 11

2. Next Generation Science / Common Core Standards Addressed! HS ‐ LS4 ‐ 4. Construct an explanation based on evidence for how natural selection leads to adaptation of populations. [Clarification Statement: Emphasis is on using data to provide evidence for how specific biotic and abiotic differences in ecosystems (such as ranges of seasonal temperature, long ‐ term climate change, acidity, light, geographic barriers, or evolution of other organisms) contribute to a change in gene frequency over time, leading to adaptation of populations.] HS ‐ LS2 ‐ 8. Evaluate the evidence for the role of group behavior on individual and species’ chances to survive and reproduce[Clarification Statement: Emphasis is on: (1) distinguishing between group and individual behavior, (2) identifying evidence supporting the outcomes of group behavior, and (3) developing logical and reasonable arguments based on evidence. Examples of group behaviors could include flocking, schooling, herding, and cooperative behaviors such as hunting, migrating, and swarming.]

3. Bell Work List types and methods of animal research. Describe what animals are used in laboratory research. Explain models and management used for laboratory animals.

4. Terms Animal by-product tissue Applied research Basic research Clinical research Laboratory animals Living animals Nonhuman primates Nonliving research

5. Interest Approach Ask the question: “How do humans know if products are safe for use?” Generate discussion on the benefits of using animals to test products and provide medical advances.

6. List types and methods of animal research.

7. What types and methods are used for animal research? Laboratory animals –Animals - used and raised for research done in laboratories –provided many advances for humans –pros and cons for using animals for research –benefit to human health has been extremely important

8. Types of Research Animal by-product tissue animal tissue taken from animals and then used for other purposes parts taken are from tissue, organs, and any other needed parts Basic Research research carried out in nature or in a lab that will increase understanding of diseases and life processes used to provide data and usually does not have a predetermined goal

9. Types of Research Applied Research Research that has a specific goal, like developing a vaccine for a disease Clinical Research research that focuses on a specific problem and is conducted in a medical facility often uses the species that is intended to benefit as subjects New drug development for example

10. Describe what animals are used in laboratory research.

11. What animals are used in lab research? Many species are used for research ability to live in very little space and reproduce quickly makes some animals better suited for research.

13. What animals are used in lab research? Mice account for over 90% of animals used small, easy to handle, reproduce quickly and require little money to keep Rats mainly for behavior and nutrition studies require little space well tempered Hamsters small, stout, furry animals more aggressive than mice and rats care needs to be taken when handling Guinea pigs similar to hamsters very calm easier to handle reproduce quickly live successfully in a confined area

15. What animals are used in lab research? Rabbits used for drug testing they experience some of the common ailments of humans Cats studies with the brain research is easier since brain is less complicated Dogs used in lab research surgical studies physiological experiments more space is required to house them

16. What animals are used in lab research? Nonhuman Primates animals that are more similar to humans than any other animal monkeys communication experiments Other Creatures lobsters used to study nerves since their nervous systems are simple

17. Explain models and management techniques used for laboratory animals. Objective #3

18. What models and management techniques are used for lab animals? use of animals for research is a well managed in a strictly controlled area models have been developed to ensure proper use of lab animals 4 basic research animal models –living animals –tissue cultures –nonliving systems –human-created computer models

19. What models and management techniques are used for lab animals? Living animal –one that is used when it is alive and can respond to treatments –only used when it is completely necessary Tissue cultures –taken from animals and then used in experiments Nonliving research –done to relate movement or injury to animal systems Computer models –used to quicken experiment results

20. What models and management techniques are used for lab animals? Many specific regulations Must meet acceptable standards approved by the Institutional Animal Care and Use Committee Allowed based on the Animal Welfare Act of 1985 –enacted to assure acceptable use of animals Inspections done by Animal and Plant Health Inspection Service and the Public Health Service in every state.

21. What models and management techniques are used for lab animals? 2 basic animal needs that are monitored –Nutrition –Environment Nutrition –keep animals well fed –malnutrition could affect experiment results

23. Review What types and methods are used for animal research? What animals are used in lab research? What models and management techniques are used for lab animals?

24. The End!