1. ATI Neurostimulation system:
Electronic Aspirin
Presentation by: Sarah Borges

2. ATI Neurostimulation System
Known commonly as “Electronic aspirin”
Only one company developing this device- ATI
Consists of 2 separate pieces
Remote control
Implantable device
Designed to treat cluster headaches

3. Cluster headaches Also known as “suicide” headaches
Condition of severe unilateral temporal/orbital pain
Headaches last 15 min-3 hours
Symptoms include:
Watery eyes
Droopy eyelid
Nasal congestion
Localized swelling
Associated with the SPG (sphenopalatine ganglion) bundle
Affects 0.2% of United States population

4. Other Treatment Methods
Oxygen treatment with a tank
Cumbersome
Oral medication
Run the risk of an allergic reaction
Sphenopalatine ablation
Killing local SPG area via heat
Last resort: can lead to partial facial paralysis

5. ATI System Design Two separate parts:
Device
Almond-sized
2 terminals
Remote control
Hand-held, rechargeable
Upon onset of headache, patient places remote to device, sending electrical signal to device
Device stimulates SPG bundle in a way that prevents the release of pain-related neurotransmitters

6. implantation procedure
Surgery is about as extensive as removal of wisdom teeth
~1-3 hours in length
Device is implanted on the side of the head patient experiences headaches more: within gum tissue, below eye

7. Current results System still in clinical trial phase
Currently testing device on 120 patients since
Will continue monitoring patients for one year
Preliminary results:
75% patients have recorded improvement in their ability to function normally in their daily lives
68% report experiencing less severe headaches
31% report a decrease in the amount of headaches they have weekly

8. Benefit of ati system over other treatments
Less bulky/more conspicuous than an O2 tank
Does not risk patient having an allergic reaction or conflicting prescriptions for other health implications
Unlike ablation, ATI system has temporary effects
ATI system can be removed if need be

9. Foreseen disadvantages
More difficult to stop treatment than O2 tank/oral medications: need surgery to remove
Can only treat one side of head
Have to remember to charge remote control and bring everywhere
Electronic device: has the potential to malfunction
Only treatment for patients of cluster headaches

10. Future direction FDA approval
Design to make available to patients suffering from migraines, tension headaches, and other types of facial pain due to other conditions they may have

11. references
Bahra, Anish, et al. "Cluster Headache: A Prospective Clinical Study with Diagnostic Implications." Neurology58.3 (2012):  Neurology. Web. 2 Nov. 2014
Sphenopalatine Ganglion Stimulation for the Treatment of Chronic Cluster Headache<
results/NCT ?term=autonomic+technologies>
Electronic Aspirin <
sciplanetdetails.aspx?id=104>
Wikipedia: Cluster Headache <
/Cluster_headache>
Zapping the Sphenopalatine Ganglion < sphenopalatine-ganglion/
"News Europe: Neurostimulation: Gingival Implant Helps Reduce Cluster Headache." RSS. Dental Tribune International, 6 Mar Web. 12 Nov
Hanna, M. "Migraine Headaches, Tension Headaches, and Cluster Headaches." Dr. M. Hanna, n.d. Web. 10 Nov <