1. Nobel Prize Heritage of the CWRU Department of Pharmacology
Earl W. Sutherland, Jr
Discovery of Cyclic AMP
Ferid Murad
Nitric Oxide Signaling
Nobel Prize
Alfred G. Gilman
G-protein Signal Transduction

2. First high resolution structure of a G-protein coupled receptor (GPCR)
most common target of modern drug development
In the top five of most highly cited articles in Biology / Biochemistry
Thomas Reuters Survey
Continuing Tradition of Excellence in Pharmacology at CWRU
Kris Palczewski, Chairman of Pharmacology

3. Pharmacology Core Course
Molecular Therapeutics
Training Program ( MTTP )
Translational Therapeutics
Membrane
Structural Biology &
Pharmacology
The NIH-funded Molecular Therapeutics Training Program (MTTP) involves faculty from six major research centers in Cleveland - CWRU, University Hospitals, Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland VA Medical Center, and MetroHealth Medical Center.
Students enter the Pharmacology Graduate Program directly, or via the Biomedical Sciences Training Program (BSTP) or the Medical Sciences Training Program (MSTP).
Pharmacology Core Course
Cellular / Molecular Biology & Research Rotations
Note the poster was originally sized as 24 x 36 inches.
Prelim Exams
Molecular Pharmacology
& Cell
Regulation
Cancer
Therapeutics
Core and Advanced Tracks
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

4. Pharmacology Core Course
Molecular Therapeutics
Training Program ( MTTP )
Translational Therapeutics
Membrane
Structural Biology &
Pharmacology
The Molecular Pharmacology and Cellular RegulationTrack promotes common research interests in molecular mechanisms of drug actions and regulatory processes that are potential targets for drug development.
Pharmacology Core Course
Cellular / Molecular Biology & Research Rotations
Prelim Exams
Molecular Pharmacology
& Cell
Regulation
Cancer
Therapeutics
Core and Advanced Tracks
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

5. Molecular Pharmacology and Cellular Regulation Track
Novel role of ATP as a chemoattractant that facilitates
the immune component of the anti-tumor response
associated with cancer chemotherapy …
Andrea Boyd-Tressler and George Dubyak
Luke Bury and Shasta Sabo
Modern electrophysiology and imaging used to discover the mechanisms by which nerve synapses are formed in the developing brain - discovering the basis for autism …
Meghana Gupta and Danny Manor
Learning how phosphorylation of tyrosine residues affects the biochemical and physiological activities of proteins that regulate G-protein signaling – discovering anti-cancer targets …

6. Pharmacology Core Course
Molecular Therapeutics
Training Program ( MTTP )
Translational Therapeutics
Membrane
Structural Biology &
Pharmacology
Pharmacology Core Course
Benefiting from the Case Comprehensive Cancer Center, the Cancer Therapeutics Track fosters common interest in the concepts of cancer biology that form the basis for specific therapeutic strategies.
Cellular / Molecular Biology & Research Rotations
Note the poster was originally sized as 24 x 36 inches.
Prelim Exams
Molecular Pharmacology
& Cell
Regulation
Cancer
Therapeutics
Core and Advanced Tracks
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

7. Cancer Therapeutics Track
Studies of mechanisms of regulation of lymphocyte apoptosis via the TDAG8 G protein-coupled receptor in the context of leukemia.…
Chris Ryder Clark Distelhorst
“The role of the microenvironment in mediating breast cancer progression.  Specifically I'm interested in the role of microRNAs on TGF-beta mediated-metastatic progression…”
MollyTaylor Billl Schiemann

8. Pharmacology Core Course
Molecular Therapeutics
Training Program ( MTTP )
Translational Therapeutics
Membrane
Structural Biology &
Pharmacology
Pharmacology Core Course
The Translational Therapeutics Track interfaces basic science trainees with physician-scientists around a common interest in developing / improving the use of therapeutic agents in a rational and individualized manner.
Cellular / Molecular Biology & Research Rotations
Note the poster was originally sized as 24 x 36 inches.
Prelim Exams
Molecular Pharmacology
& Cell
Regulation
Cancer
Therapeutics
Core and Advanced Tracks
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

9. Translational Therapeutics Track
Antiplatelet therapeutics…”my project examines an agent that has ideal characteristics; it delays thrombosis but does not influence bleeding time…”
Michele Mumaw Marvin Nieman
Structure function studies of Class A beta-lactamases. Understanding the factors that permit the successful evolution of beta-lactamases in the clinic…
Peter Levitt Robert Bonomo
“I study the role of DNA repair in hematopoietic stem cells to understand the relationship between DNA repair, cell cycle status, and hematopoietic stem cell function.…”
Amar Desai Stan Gerson

11. Structural Biology & Pharmacology Track
Mike Mullins
Understanding the function of telomerase in DNA replication pertaining to aging and cancer chemotherapy
Derek Taylor …
Chris Francy
Jason Mears
Studying the molecular dynamics of Drp 1 in mediating mitochondrial fission & fusion pertinent to neurodegenerative diseases
Solving high resolution 3-dimensional structures of individual molecules and macromolecular complexes to inform functional insights:
Determining the structure of isolated discs from the rod cells of the eyes of mouse models of human eye diseases
Neetu Gulati
Phoebe Stewart
Director, CCMSB

12. Electron Microscopy
NMR
X-ray generator
Crystal robot
Mass spec, computational modeling, one of the 3 largest, best equipped facilities in the world!