1. Enantioselective Total Synthesis of Ecteinascidin 743
Nan Li

2. Ecteinascidin 743, a tetrahydroisoquinoline alkaloid, was isolated from the Caribbean tunicate Ecteinascidia turbinata by Rinehart and co-workers. This alkaloid attracted strong interest as a potential anticancer agent because of its combination of strong cytostatic properties and antitumor activity, and it has recently been approved for the treatment of soft tissue sarcoma and ovarian cancer.
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3. Corey, E. J. Total Synthesis of Ecteinascidin 743

10. Zhu, J. P. Total Synthesis of Ecteinascidin 743

15. Fukuyama, T. Total Synthesis of Ecteinascidin 743

19. Curtius rearrangement
Strecker reaction

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23. Pictet-Spengler reaction