1. Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden Featured Article: Tom W.C. Lung, Dennis Petrie, William H. Herman, Andrew J. Palmer, Ann-Marie Svensson, Bjorn Eliasson, and Philip M. Clarke Diabetes Care Volume 37: 2974-2981 November, 2014

2. STUDY OBJECTIVE To examine whether previous severe hypoglycemic events were associated with the risk of all-cause mortality after major cardiovascular events in type 1 patients Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981

3. STUDY DESIGN AND METHODS Data were from the Swedish National Diabetes Register Patients included those with type 1 diabetes who visited a clinic during 2002–2010 and experienced a major cardiovascular complication after the visit Two-part model was estimated for all-cause mortality after a cardiovascular event: 1.Logistic regression for death within the first month 2.Cox proportional hazards model conditional on 1- month survival 5-year cumulative mortality risk was estimated from the models for patients with and without prior diabetes complications Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981

4. RESULTS 1,839 patients experienced major cardiovascular events 403 had previously experienced severe hypoglycemic events 703 died within our study period A prior hypoglycemic event was associated with a significant increase in mortality after a cardiovascular event Patients with prior hypoglycemia had an estimated 5-year cumulative mortality risk of 52.4 and 39.8% for myocardial infarction and stroke, respectively Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981

8. CONCLUSIONS Patients with type 1 diabetes in Sweden with prior severe hypoglycemic events have increased risk of mortality after a cardiovascular event Lung T. W.C. et al. Diabetes Care 2014;37:2974-2981