1. Autonomic Nervous System Dr Dileep Verma Associate Professor Deptt of Physiology KGMU

2. Lecture-2 :Topics Neurotransmitters of ANS Receptors of ANS - Adrenergic - Cholinergic

3. Learning Objectives List different types of adrenergic & cholinergic receptors with their location Various autonomic neurotransmitters. Mechanisms of neurotransmitter release in the sympathetic and parasympathetic divisions.

4. Autonomic nervous System Neurotransmitters of ANS  Neurotransmitters of sympathetic nervous system  Neurotransmitters of parasympathetic nervous system

5. Sympathetic Nervous System Neurotransmitters at- A. Preganglionic nerve endings B. Postganglionic nerve endings C. Target tissue

6. Sympathetic Nervous System Neurotransmitters at- A. Preganglionic nerve endings  Acetylcholine (ACh) B. Postganglionic nerve endings  Norepinephrine (NE)  Acetylcholine (ACh)

7. Sympathetic Nervous System Neurotransmitters at- Target tissue  Epinephrine (Ep)  Norepinephrine (NE)  Acetylcholine (Ach)

8. Parasympathetic Nervous System Neurotransmitters at- A. Preganglionic nerve endings  Acetylcholine (ACh) B. Postganglionic nerve endings  Acetylcholine (ACh)

9. Autonomic nervous System Receptors of ANS A. Receptors of Sympathetic Nervous System B. Receptors of Parasympathetic Nervous System

10. Autonomic nervous System Receptors of ANS A. Receptors of Sympathetic Nervous System B. Receptors of Parasympathetic Nervous System

11. Autonomic nervous System Receptors of ANS A. Receptors of Sympathetic Nervous System  Adrenergic Receptors  Cholinergic Receptors B. Receptors of Parasympathetic Nervous System  Cholinergic Receptors

12. Adrenergic Receptors Alpha adrenergic  Alpha-1 (    Excitatory  Alpha-2 (    Inhibitory Beta adrenergic  Beta-1(   )- Excitatory  Beta-2 (    Inhibitory   Beta-3 (    Excitatory

13. Alpha adrenergic receptor (  ) Alpha-1 (    Excitatory  Vascular smooth muscles  Skin  Splanchnic region  GI wall  Sphincters  Radial muscle of iris Alpha-2 (    Inhibitory  Presynaptic nerve terminal  Platelets  GI wall

14. Beta adrenergic receptor (  ) Beta-1(   )- Excitatory  SA Node  AV Node  Myocardium Beta-2 (    –Inhibitory  Vascular smooth muscles  Skeletal muscle  Bronchial smooth muscles  GI Wall Beta-3 (    Excitatory  Adipose tissue

15. Cholinergic Receptor Cholinergic Receptors- Cholinergic Receptors- 2 types Receptors (N) Nicotinic Receptors (N)  Nicotinic Neuronal (N  ) Type  Nicotinic Muscular (N  ) Type Receptors (M) Muscarinic Receptors (M)  M1 to M7

16. Nicotinic Neuronal (N  ) Type Location - Autonomic ganglia Activated by-  Ach  Nicotine Effect – Excitatory or Inhibitory Blocked by- Hexamethonium

17. Nicotinic Muscular (N  ) Type Location - Neuromuscular Junction Activated by-  Ach  Nicotine Effect – Always Excitatory Blocked by- Curare

18. Muscarinic receptor Location -  Myocardium  Glands  Smooth muscle Activated by-  Ach  Muscarine Effect – Inhibitory/Excitatory Blocked by- Atropine

19. At Sweat Gland  Neurotransmitter-Acetylcholine  Receptors- Muscarinic At the adrenal cortex  no postsynaptic neuron  Neurotransmitter-Acetylcholine  Receptors- Nicotinic

20. 1- Sympathetic postganglionic fibres to sweat gland secrete-- A. Acetylcholine B. Norepinephrine C. Epinephrine D. Serotonin

21. 2-Acetylcholine through nicotinic receptors causes- - A. Constriction of pupil B. Secretion of saliva C. Decreases the heart rate D. Contraction of skeletal muscle

22. 3-.Stimulation of alpha adrenergic receptors results in- A.Pupillary dilatation B.Glycogenolysis C.Inhibit intestinal motility D.All of the above

23.     adrenergic receptors are located on/in A.Presynaptic nerve terminal B.Platelets C.GI wall D.Radial muscle of iris

24. 5-Which is true about    adrenergic receptors ? A. Located on adipose tissue B. More sensitive to epinephrine C. Stimulate glycogenesis D. Inhibits lipolysis