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Substance abuse prevention Gilberto Gerra Chief Drug Prevention and Health Branch.

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Presentation on theme: "Substance abuse prevention Gilberto Gerra Chief Drug Prevention and Health Branch."— Presentation transcript:

1 Substance abuse prevention Gilberto Gerra Chief Drug Prevention and Health Branch

2 and vulnerability Exploring resilience...

3 Identifying risk conditions

4

5 Biol Psychiatry Lasting epigenetic influence of early-life adversity on the BDNF gene. Roth et al., 2009 brain-derived neurotrophic factor (BDNF) gene first postnatal week infant rats exposed to stressed caretakers with abusive behaviors persisting changes in methylation of BDNF DNA that caused altered BDNF gene expression in the adult prefrontal cortex BDNF DNA methylation in offspring of females that had previously experienced the maltreatment regimen

6 Proceedings of the Naional Academy of Sciences of the United States of America (PNAS), 2012

7 Epigenetic effects of drugs

8 Epigenetic mechanisms in drug addiction Renthal and Nestler, 2009

9

10 Submitted twice or more times to epigenetic effects: 1) During the clinical history 2) During the exposure to drugs

11

12 Prevention of substance abuse reaching the most vulnerable Prevention of substance abuse as a pillar of development and freedom

13

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