1. Rashid A. Chotani, MD, MPH Adjunct Professor, GWU Chotani@gwu.edu

2. Highlights as of 17 December, 2014  Reported Cases 18,603 (11 Dec = 17,942; up by 661; Less compared to previous week)  Reported Deaths 6,915 (11 Dec = 6,388; up by 527; High compared to previous week)  Overall CFR = ~37% (05 Dec = 36%)  Highest number of cases in 45+ age group; four times more likely to be affected (slide # 5)  Case incidence  Fluctuating/Study in Guinea  76 new confirmed cases were reported nationally during the week to 14 December  Overall Proportion: 22 cases and 14 deaths per 100,000 population  Study/Declining in Liberia  6 districts reporting new confirmed or probable cases in the week to 14 December  Overall Proportion: 197 cases and 83 deaths per 100,000 population  Increasing in Sierra Leone (Now highest # of Cases Reported)  327 new confirmed cases reported in the week to 14 December  Overall Proportion: 145 cases and 36 deaths per 100,000 population  The UN Mission for Ebola Emergency Response (UNMEER) targets of isolating and treating 100% of EVD cases and burying 100% of EVD related deaths safely by 01 January, 2015, continue to progress in Guinea, Liberia, and Sierra Leone  All 3 countries have:  Sufficient capacity at a national level to meet both targets, though local variations means capacity is still insufficient to stop transmission in some areas  Access to a laboratory within 24 hours from sample collection.  Reported that more than 80% of registered contacts associated with known cases of EVD are being traced, although contact tracing is still a challenge in areas of intense transmission and in areas of community resistance. Source: WHO/CDC/SOS International

3. Overall Status as of 17 December, 2014 Senegal declared outbreak free: 17 October Nigeria declared outbreak free: 19 October Spain declared outbreak free: 02 December = Ebola Free These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International

4. HCW Status as of 17 December 2014 Total Cases 649 (up 10 from 639 on 11 Dec) Total Deaths 365 (up 15 from 349 11 Dec) Case-Fatality Rate ~ 56% One death in USA was a HCW infected in Guinea These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International For each country the first three bars represent cases & the subsequent three bars represent deaths

5. Country Cumulative Cases By Gender* (per 100,000 population) By Age Strata # (per 100,000 population) MaleFemale0-14 years15-44 years45+ years Guinea 1017 (19) 1090 (20) 329 (7) 1216 (26) 545 (35) Liberia 2538 (128) 2444 (124) 831 (48) 2653 (155) 1015 (190) Sierra Leone 3112 (109) 3291 (113) 1274 (53) 3587 (139) 1449 (196) Total 6667 (65) 6825 (66) 2434 (28) 7456 (83) 3009 (106) Cumulative number of confirmed and probable cases by Gender and Age Strata in Guinea, Liberia, and Sierra Leone Population figures are based on estimates from the United Nations Department of Economic and Social Affairs. *Excludes cases for which data is not available on gender. # Excludes cases for which data on age are not available. These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: UNDESA/WHO