1. Tissues and Organs Comprising the Immune Response System Where components of the immune response originate, differentiate, meet, interact, and function Folder Title: Tiss&Org Updated: October 30, 2014

2. APC and T-Cells

3. Marcophage and T-Cell Kissing

4. Macrophage to T-Cell Interaction

5. Helper T-cell B-Cell Interaction CD4 co-receptor

6. B-Cell Activation See figure 2-7, Kuby, 4th Ed., p. 36

7. B-Cell: Small, Blast, and Plasma See Figure 2-7, Kuby 4th Ed. p. 36

8. Where do these cells originate? Where do they go to interact with each other? Where do they carry out their functions?

9. Primary and Secondary Lymphoid Related to Figure 2-13, Kuby, 4th Edition, p. 47

11. Animations Produced for Kuby Immunology Online Link http://bcs.whfreeman.com/immunology6e/ (In Class Do animations from the Book CD) Chapter 2 Animation. Cells and Organs

12. Exactly* what kind of Cell is the one attached to the B-Cell? *(“exactly” means not just its general type of cell, but specifically what type of cell it is based on what this figure shows that the cell is doing) RankResponses 1 2 3 4 5 6Other

13. Thymus Photo

14. Thymus Cartoon Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross

15. CD4 and CD8 in Thymus

16. MALT and M-Cells See Figure 2-22, Kuby 4th Ed. p. 56

19. MALT and IgA See Figure 2-22 Kuby, 4th Ed. p. 56

20. CD Antigen Table CDMarks

21. CD Antigens Color Coded

22. Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Chapter 11 Animation. Signal Transduction

23. CD Antigen List: Pages A1 to A26: 339 Entries, 2007 Edition of Kuby How to Understand CD Antigens: 5 Persons in a Room Person 1: 5 ft 5”, 160 lbs bespectacled old geezer Person 2: 5 ft 11”, 280 lbs, 22-year old guy, all muscle Person 3: 5 ft 5”, 135 lbs, 20-year-old woman Person 4: 7 ft 1”, 200 lbs, 22 year-old guy Person 5: 5 ft 8”, 150 lbs, 22 year-old guy

24. This is a fill-in-the-blank question. Please enter your responses as a series of numbers from 1 to 5. Which Person: A. Is a varsity basketball player? B. Plays on the women’s field-hockey team? C. Is a boring old professor? D. Is a varsity football player for SU? E. Is a cross-country runner? __ __ __ __ __ Person 1: 5 ft 5”, 160 lbs bespectacled old geezer Person 2: 5 ft 11”, 280 lbs, 22-year old guy, all muscle Person 3: 5 ft 5”, 135 lbs, 20-year-old woman Person 4: 7 ft 1”, 200 lbs, 22 year-old guy Person 5: 5 ft 8”, 150 lbs, 22 year-old guy

25. Secrets of Signaling 1. How Do You Knock on a Door? 2. Why does the phone “ring” more than once? 3. Why can the police officer directing traffic blow his whistle only once? 4. Why does your computer say “Are You Sure You Want to Delete File XYZ?” 5. When the class was directed to do “Bunny Ears” behind the person next to them, only a few persons responded. Why was that? 6. A different set of persons responded when asked to raise their right hand. Why was that?

26. Secrets of Signaling (2) 7. Only the guys in the front of the room responded when I invited the class to do what all classes would love to do to a pain-in-the next Prof. Why was that? 8. I asked the class to raise both hands but no one complied. Why is that?

27. Signal, Receptors, and co-receptor Pairs

28. Costimulatory signals: B7 – CD28

29. Costimulatory Signals: T-Cell to MPh

30. Cancer Eluding Costimulatory Signal

31. CD’s on B, T, and NK Cells

32. T-Cell ALL Markers Kuby, 5 th Edition p. 157 (“ALL” = Acute Lymphocytic Leukemia)

33. Pre-B-Cell ALL Markers Kuby, 5 th Edition p. 157 (“ALL” = Acute Lymphocytic Leukemia)

34. B-Cell CLL Markers Kuby, 5 th Edition p. 157 (“CLL” = Chronic Lymphocytic Leukemia)

35. Leukocyte Recirculation

36. Lymphocyte Recirculation

38. Leucocytes in Capillaries Cartoon

39. Leucocytes in Capillaries Photo

40. Extravasation of Naïve T-Cell into Lymph Node

41. Adhesion: Leucocytes to Endothelium

43. (Non-inflamed Endothelium)

44. CAM = Cell Adhesion Molecules

45. General Structures of Cell Adhesion Molecules (CAMs) Kuby, 3rd Edition Figure 15-2a Endothelial Cells Lining Capillaries CAMStruct Membrane of Circulating Leucocytes

46. (Inflamed Endothelium)

47. CAMinCap Adhesion in Capilaries

48. Animations Produced for Kuby Immunology OnLine Link http://bcs.whfreeman.com/immunology6e/ In Class Use Book CD: Chapter 2: Cells of the Immune-system (Static) Cell Death : (Animated) Chapter 11: Signal Transduction (Animated) Chapter 4 : Immunoglobulins (Static) Chapter 13 Animation. Leukocyte Extravasation (Animated)

49. Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students.

51. Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Or search “Kuby Immunology”, Click on “Kuby Immunology 6e”, go to Student Resources Chapter 2: Cells Cell Death (Also chapter 10) Chapter 11: Signal Transduction Chapter 13: Leucocyte Extravasation

52. Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix Figure 19-14 ECB 1998, p. 603 Plasma Membrane Collagen Integrin Fibronectin Actin Microfilament MFtoECM

53. CAMFamly On Endothelial Cells On Neutrophils On Mucosal Epithelium On Leucocytes On Endothelial Cells On Leucocytes On Endothelial Cells Families of Cell Adhesion Molecules Kuby, 3rd Ed. Figure 15-2b CamFamly Leucocyte CAM in Blue Tissue-target Cells in Red