1. BIO341 Meiotic mapping of whole genomes (methods for simultaneously evaluating linkage relationships among large numbers of loci)

11. From: Principles of Genetics. 1997. Snustad et al.

14. Linkage analysis of Elliptocytosis and Rh factor From: Principles of Genetics. 1997. Snustad et al.

15. Summary LOD score analysis of linkage compares two possibilities: two loci are (a) linked at some specified recombination frequency and (b) are unlinked (rec. =50%). LOD = log 10 (probability of a genotype under a/ probability of the same genotype under b) Each progeny individual makes a positive or negative contribution to LOD. LOD scores of progeny from different families or crosses can be combined. A LOD score total of 3.0 or greater is generally considered strong evidence of linkage. Recombination frequency itself can be estimated by calculating LOD for different recombination values. The recombination frequency resulting in the maximum LOD score is treated as the most likely.