Presentation is loading. Please wait.

Presentation is loading. Please wait.

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito.

Published byBarry Watts Modified over 9 years ago

Similar presentations

Presentation on theme: "Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito."— Presentation transcript:

1 Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito Endo, Okiru Komine, Noriko Fujimori-Tonou, Masahisa Katsuno, Shijie Jin, Seiji Watanabe, Gen Sobue, Mari Dezawa, Tony Wyss-Coray, Koji Yamanaka Cell Reports Volume 11, Issue 4, Pages 592-604 (April 2015) DOI: 10.1016/j.celrep.2015.03.053 Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

2 Figure 1 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

3 Figure 2 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

4 Figure 3 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

5 Figure 4 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

6 Figure 5 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

7 Figure 6 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

8 Figure 7 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

9 Cell Reports 2015 11, 592-604DOI: (10.1016/j.celrep.2015.03.053) Copyright © 2015 The Authors Terms and Conditions Terms and Conditions

Download ppt "Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Fumito."

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti

Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Xing Zhang, Lei Jin, Qin Fang, Wong H. Hui, Z. Hong Zhou Cell.

3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Xing Zhang, Lei Jin, Qin Fang, Wong H. Hui, Z. Hong Zhou Cell.
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J.

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J.
Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors Liang Yang, Yong Qi, Yunlei Yang Cell Reports Volume 11, Issue.

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors Liang Yang, Yong Qi, Yunlei Yang Cell Reports Volume 11, Issue.
Irreplaceability of Neuronal Ensembles after Memory Allocation Naoki Matsuo Cell Reports Volume 11, Issue 3, Pages 351-357 (April 2015) DOI: 10.1016/j.celrep.2015.03.042.

Irreplaceability of Neuronal Ensembles after Memory Allocation Naoki Matsuo Cell Reports Volume 11, Issue 3, Pages (April 2015) DOI: /j.celrep
Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division J. Peter Etchells, Laxmi S. Mishra, Manoj Kumar, Liam Campbell, Simon.

Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division J. Peter Etchells, Laxmi S. Mishra, Manoj Kumar, Liam Campbell, Simon.
Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors Delphine Delaunay, Véronique Cortay, Dorothée.

Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors Delphine Delaunay, Véronique Cortay, Dorothée.
Consecutive Positive Feedback Loops Create a Bistable Switch that Controls Preadipocyte-to-Adipocyte Conversion Byung Ouk Park, Robert Ahrends, Mary N.

Consecutive Positive Feedback Loops Create a Bistable Switch that Controls Preadipocyte-to-Adipocyte Conversion Byung Ouk Park, Robert Ahrends, Mary N.
Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy Christian J. Niedworok, Inna Schwarz, Julia Ledderose, Günter.

Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy Christian J. Niedworok, Inna Schwarz, Julia Ledderose, Günter.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages 38-52 (April 2008) DOI: 10.1016/j.cell.2008.03.011.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome David A. Orlando, Mei Wei Chen, Victoria E. Brown, Snehakumari Solanki,

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome David A. Orlando, Mei Wei Chen, Victoria E. Brown, Snehakumari Solanki,
Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: 10.1016/j.cell.2012.01.031 Copyright © 2012 Terms and Conditions Terms and Conditions.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.
Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1 Dong-Yan Jin, Forrest Spencer, Kuan-Teh Jeang Cell.

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1 Dong-Yan Jin, Forrest Spencer, Kuan-Teh Jeang Cell.
Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz,

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz,
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages 232-237 (January.

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes Chih-Ying Lee, Henning F. Horn, Colin L. Stewart, Brian Burke,

Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes Chih-Ying Lee, Henning F. Horn, Colin L. Stewart, Brian Burke,
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease Roshni Srivastava, Jiasheng Zhang, Gwang-woong.

Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease Roshni Srivastava, Jiasheng Zhang, Gwang-woong.
Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages 180-190 (April 2010) DOI: 10.1016/j.tics.2010.01.008.

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics

Similar presentations

Ads by Google