1. Cell and Molecular Biology Fifth Edition CHAPTER 7 Part 3 Interactions Between Cells and Their Environment Copyright © 2008 by John Wiley & Sons, Inc. Gerald Karp

2. 3. Adherin junctions and desmosomes Calcium-dependent adhesive junction (difficult to separate)

3. The structure of adherens junction The adherenes junctions situated between ECs that line the walls of blood vessels transmit signals that ensure the survival of the cells. Mutation …..die in embryonic stage

4. The role of cell-adhesion receptors in Transmembrane signaling: Integrins and cadherins can transmit signals from extracellular space to the cytoplasm with the cytoskeleton and the cytosolic regulatories molecules, causing PKs activation and changes in pH or Ca 2+ conc. phosphorylation, and gene expression.

5. 7.4 Tight junctions Sealing the extracellular space

6. 7.5 Gap junction and plasmodesmata: mediating intercellular communication Gap junction plasmodesmata