1. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Cancer Chapter 12

2. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. What Is Cancer? Abnormal, uncontrolled cellular growth Benign versus malignant tumors Malignant tumor = cancerous and capable of spreading; neoplasm Benign tumor = noncancerous and nonspreading

3. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. What Is Cancer? 1.3 million cases of cancer per year; 550,000 deaths

4. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. How Cancer Spreads: Metastasis Metastasis Spread of cancer cells from one part of the body to another Blood vessels Lymphatic system Secondary tumors or metastases

5. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. How Cancer Spreads: Metastasis Carcinogen Any substance that causes cancer

6. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Tumor Development Tumor development begins when a cell sustains a genetic mutation that increases its propensity to divide when it would normally rest

7. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Tumor Development The altered cell and its descendants continue to look normal but reproduce too much (hyperplasia) One in a million of these altered cells will suffer another mutation that further loosens control on cell growth

8. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Tumor Development Descendants of this cell appear abnormal in shape (dysplasia) Affected cells become increasingly abnormal in growth and appearance

9. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Tumor Development If the tumor begins to invade underlying tissue and shed cells into the blood or lymph, it is considered malignant and can establish new tumors throughout the body

10. Male Cancer Death Rates 1930 – 2000 Source: American Cancer Society Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved.

11. Female Cancer Death Rates 1930 – 2000 Source: American Cancer Society Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved.

12. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Common Cancers Lung Cancer Colon and Rectal Cancer Breast Cancer Prostate Cancer

13. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Lung Cancer Leading cause of cancer death Chief risk factor = smoking ETS causes about 3000 lung cancer deaths per year

14. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Lung Cancer Symptoms Persistent cough, chest pain Treatment Combination of surgery, radiation, chemotherapy Survival rate 15% after five years

15. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Colon and Rectal Cancer Second leading cause of cancer death Risk factors Age Preexisting polyps Heredity Inactivity and obesity Diets high in red meat, smoked foods, simple sugars Excessive alcohol consumption Smoking

16. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Colon and Rectal Cancer Symptoms Bleeding from the rectum Change in bowel habits Testing Stool blood test Sigmoidoscopy or colonoscopy Treatment Surgery is primary method of treatment

17. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Breast Cancer Most common cancer in women and second to lung cancer in the number of cancer deaths among women

18. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Breast Cancer Causes / risk factors Heredity Long - term exposure to high blood levels of estrogen Early onset of menstruation Late onset of menopause No children or first child after age 30 Obesity Current use of HRT Alcohol use

19. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Breast Cancer Causes / risk factors Inactivity Diet low in vegetables and fiber

20. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Breast Cancer Early detection Mammography (low - dose X ray) after age 40 Clinical breast exams Breast awareness and self - examinations

21. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Breast Cancer Diagnosis Ultrasonography = imaging method using high - pitched sound Biopsy = removal and examination of a small piece of body tissue Treatment Surgery (lumpectomy, mastectomy) Chemotherapy or radiation, social support

22. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Prostate Cancer Most common cancer in men and second to lung cancer in the number of cancer deaths among men

23. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Prostate Cancer Risk factors Age African American ethnicity Heredity Lifestyle factors Diets high in calories, dairy products, and animal fat and low in plant foods Obesity and inactivity History of STDs

24. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Prostate Cancer Detection and diagnosis Rectal exam PSA (prostate - specific antigen) blood test Ultrasound Biopsy

25. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Prostate Cancer Treatment Surgery Radioactive seeds Survival rate 98% at five years

26. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Cancers of the Female Reproductive Tract Cervical Cancer Uterine or Endometrial Cancer Ovarian Cancer

27. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Cervical Cancer Linked to infection with HPV (genital warts) Detected with the Pap test Scraping of cells from the cervix for examination

28. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Cervical Cancer Abnormal cells are monitored over time If they progress toward malignancy, they are removed

29. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Uterine or Endometrial Cancer Risk factors similar to those for breast cancer Usually detected by pelvic examination

30. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Uterine or Endometrial Cancer Treatment Surgery, possibly combined with radiation and chemotherapy Survival rate 96% at five years

31. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Ovarian Cancer Risk factors similar to breast and endometrial cancer Anything that lowers the lifetime number of ovulation cycles reduces risk Usually has no symptoms and is difficult to detect

32. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Ovarian Cancer Treatment = surgery Survival rate is low due to late detection

33. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Other Female Reproductive Tract Cancers Clear cell cancer of vagina or cervix is more common among daughters of women who took DES during pregnancy

34. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Skin Cancers Most common type of cancer when cases of the highly curable forms are included Primary risk factor is exposure to ultraviolet (UV) radiation

35. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Skin Cancers UVA Longer wavelength Damages connective tissue Leads to premature aging of the skin Causes skin cancer

36. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Skin Cancers UVB Shorter wavelength Causes sunburn Damages eyes and immune system Causes skin cancer

37. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Skin Cancers Basal Cell Carcinoma Cancer of the deepest layers of the skin Squamous Cell Carcinoma Cancer of the surface layers of the skin

38. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Skin Cancers Melanoma A malignant tumor of the skin that arises from pigmented cells, usually a mole The most dangerous form of skin cancer

39. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. ABCD Test for Melanoma A – Asymmetry Is one half unlike the other? B – Border irregularity Does it have an uneven edge? C – Color variation Is the color uniform, or does it vary? D – Diameter larger than ¼ inch at its widest point

40. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Preventing Skin Cancer Wear long - sleeved shirts, long pants, hats Use a broad - spectrum sunscreen with a high SPF (30+)

41. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Preventing Skin Cancer Apply sunscreen 30 minutes before sun exposure, 15 - 30 minutes after exposure begins, and frequently after that Apply extra sunscreen if you are using DEET

42. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Preventing Skin Cancer Avoid sun exposure between 10:00 am and 4:00 pm Check UV index Avoid tanning salons

43. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. UV Index

44. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Common Cancers Oral Cancer Key risk factors are tobacco use (including spit tobacco) and consumption of alcohol Easy to detect but difficult to treat

45. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Common Cancers Testicular Cancer Rare overall, but most common cancer in men age 20 - 35 years Can be detected with self - examination

46. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Other Cancers Pancreatic Cancer Very deadly form of cancer Bladder cancer Kidney cancer

47. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Other Cancers Brain Cancer Leukemia Cancer of white blood cells Lymphoma Cancer that begins in the lymph nodes

48. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. The Causes of Cancer: Role of DNA DNA Basics DNA Deoxyribonucleic Acid, a chemical substance that carries genetic information Chromosome Threadlike body in a cell nucleus that contains molecules of DNA

49. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. The Causes of Cancer: Role of DNA DNA Basics Gene Section of chromosome that contains the instructions for making a particular protein

50. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. The Causes of Cancer: Role of DNA DNA mutations and cancer A mutated gene no longer contains the proper code for producing its protein Oncogene Gene involved in the transformation of a normal cell into a cancer cell Cancer promoters Compounds that accelerate cell growth

51. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Causes of Cancer Dietary factors Dietary fat and meat Alcohol Fruits and vegetables Carotenoids Antioxidants Phytochemicals

52. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Dietary Guidelines for Cancer Prevention Eat a varied plant - based diet Eat five to nine servings of fruits and vegetables each day Cruciferous vegetables Citrus fruits and berries Dark - green leafy vegetables Dark - yellow, orange, or red fruits or vegetables

53. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Dietary Guidelines for Cancer Prevention Eat high - fiber foods Limit consumption of meat and total fat Favor monounsaturated and omega - 3 polyunsaturated fats

54. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Dietary Guidelines for Cancer Prevention Limit consumption of charred, blackened, cured, and smoked meat and fish Be moderate in consumption of alcohol

55. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Causes of Cancer Inactivity and obesity Carcinogens in the environment Ingested chemicals Environmental and industrial pollution Radiation Microorganisms

56. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Preventing Cancer Avoid tobacco Control diet and weight Exercise regularly Protect skin from sun Avoid environmental and occupational carcinogens Be aware of warning signs, and get recommended screening tests

57. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved. Seven Major Warning Signs of Cancer Change in bowl or bladder habits A sore throat that does not heal Unusual bleeding or discharge Thickening or lump in the breasts or elsewhere Indigestion or difficulty in swallowing Obvious change in wart or mole Nagging cough or hoarseness

58. Fahey/Insel/Roth, Fit & Well: Core Concepts and Labs in Physical Fitness and Wellness, Chapter 12 ©2007 McGraw-Hill Higher Education. All rights reserved.