1. McDaniels – Feb 8, 2008

2. Outline Patient 12 ADC results Whole lesion plots – Contour weighting factor

3. Patient 12

4. Whole lesion calculations Sum of all contours for each lesion Weighting Factor – Account for b=0 intensity variations – Account for contour area – Sum of individual Weighting Factor = 1

5. Weighting Factor I => b=0 Intensity N = Number of pixels (area) WF i = (N c *I c / Σ N*I) ADC = ΣADC i * Wf i (whole lesion)

6. Patient 6 - Original

7. Patient 6 - Weighted

8. Patient 5 - Original

9. Patient 5 - Weighted