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Cell Communication III
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G-protein linked receptor
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The structure of an inactive G-protein
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Without signaling molecule G-protein is inactive
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G-protein binds to receptor when signaling molecule is present
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G-protein accepts GTP and disassemble into two active subunits
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The α subunit of the G-protein can be deactivated through hydrolysis of GTP
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Deactivation of G-protein
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Reassembly of α subunit with other 2 subunits reforms inactive G-protein complex
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Arrestin binds phosphorylated G-protein receptor and deactivates the receptor and prepares it for endocytosis
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Activation of gene transcription by cAMP
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Synthesis and degradation of cyclic AMP
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Activation of cAMP dependent protein kinase
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Activation of gene transcription by cAMP
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Ca 2+ and diacylglycerol activate protein kinase C
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Fertilization of an egg by a sperm triggers an increase in cytosolic Ca 2+
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Ways in which a cell maintains a low Ca 2+ concentration in the cytosol
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When receptor chains crosslink the receptor is phosphorylated and activated
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Human growth hormone bound to its receptor tyrosine kinase
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Activated receptor kinase binds intracellular signaling proteins
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Ras is activated by tyrosine kinase
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The Jak-STAT signaling pathway provides a fast track to the nucleus
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