1. INTERACTION BETWEEN VIRUSES AND HOST CELLS Dr AYMAN JOHARGY 3 rd Year Medicine Clinical Microbiology 2 nd Semester Lecture 4 3 rd Year Medicine Clinical Microbiology 2 nd Semester Lecture 4

2. LEARNING OUTCOMES

3. Learning outcomes * Know determinants of viral disease * Know how viral diseases can progress inside the body? * Know determinants of viral pathogenesis * Describe types of viral infections at the cellular level * Identify mechanisms of viral cytopathogenesis * Identify viral immunopathogenesis * Describe viral epidemiology (route of transmission, terms and factors * Recognize incubation periods of representative viral diseases At the end of this lecture you should be able to:

4. OUTLINES * Determinants of viral disease * Progression of viral disease * Determinants of Viral Pathogenesis * Types of Viral Infections at the Cellular Level * Mechanisms of Viral Cytopathogenesis * Viral Immunopathogenesis * Viral epidemiology * Incubation Periods of Representative Viral Diseases

5. Viral Pathogenesis

6. Incubation Periods of Representative Viral Diseases DiseaseUsual period Short incubation (days) 1-3 D Medium incubation (days) 13-17 D Long incubation (weeks) 10-12 W Very long incubation Years

7. Viral Epidemiology

8. Route of transmission of viruses

9. Terms in Epidemiology Terms: Prevalence: Incidence: Endemic: Epidemic: Pandemic:

10. SUMMARY

11. * Determinants of viral disease * Progression of viral disease * Determinants of Viral Pathogenesis * Types of Viral Infections at the Cellular Level * Mechanisms of Viral Cytopathogenesis * Viral Immunopathogenesis * Viral epidemiology * Incubation Periods of Representative Viral Diseases