1. REVIEW I: TRANSMISSION GENETICS &exam 1: W.10.11 &chapters 1 – 5 1. genetics & the organism 2. patterns of inheritance 3. chromosomal basis of inheritance 4. eukaryotic chromosome mapping by recombination 5. genetics of bacteria & their viruses

2. &basic concepts & genetic material does what 3 things ? & patterns of transmission + meiosis = ? & what are genes & what are they doing ? &variation &continuous & discontinuous &P = G + E + G*E &norms of reaction CH01: GENETICS & THE ORGANISM

3. G 1 G 2 PHENOTYPE G ENVIRONMENT E 1 E 2 E 1 E 2 G+E E E 1 E 2 E 1 E 2 G*E NORMS OF REACTION

4. &quantitative methods &artificial selection &classical methods &mutagenesis, selection screens &map, function, molecular biology &complications &expressivity, penetrance &polygeny, pleiotropy &what is a good model organism ? CH01: GENETICS & THE ORGANISM

5. xxxx 0.05 0.10 0.15 0.20 0.25 0.30 0.35 FREQUENCY 0.00 PHENOTYPE GENETIC COMPONENT

7. &key terms on p. 24 &no assigned questions CH01: GENETICS & THE ORGANISM

8. &basic concepts & what evidence for the existence of genes ? & single genes & discrete phenotypes & what are Mendel’s laws ? & how are sex-linked genes inherited ? &Mendelian analysis &controlled breeding & terminology &1 gene: monohybrid & test cross ratios &2 genes: dihybrid & test cross ratios CH02: PATTERNS OF INHERITANCE

9. &Mendelian analysis… continued &methods: Punnet, long & short trees &formulae to predict outcomes &hypothesis testing with  2 &binomial expansion to predict outcomes &Poisson distribution to predict outcomes &sex-linked inheritance &pedigree analysis &rules & applications CH02: PATTERNS OF INHERITANCE

10. &key terms on p. 59 &all questions beginning on p. 62 CH02: PATTERNS OF INHERITANCE

11. &basic concepts & how do we know genes are on chromosomes ? & how are genes arranged on chromosomes ? & are chromosomes only genes ? & how is chromosome number maintained ? & what are the chromosomal bases of Mendel’s laws? &chromosome theory of inheritance &evidence supporting theory &chromosome structure & organization CH03: CHROMOSOMAL BASIS OF INHERITANCE

12. &mitosis & meiosis & stages & chromosome movement & differences & similarities of processes & relationships to gene transmission & fungal genetics introduced CH03: CHROMOSOMAL BASIS OF INHERITANCE

13. CHROMOSOMES & INHERITANCE

14. &key terms on p. 107 &questions 1, 2, 5-10, 12, 16, 18-20, 22, 25-30, 32, 33, 40 beginning on p. 109 CH03: CHROMOSOMAL BASIS OF INHERITANCE

15. &basic concepts & genes mapped by recombination frequencies & distances are additive &one recombination event can interfere with another &linkage & linked vs unlinked inheritance &with  2 test for linkage &linkage maps &3 point test cross CH04: CHROMOSOME MAPPING & RECOMBINATION

16. &linkage maps (continued) &accuracy in mapping by recombination &mapping function based on Poisson disctribution &single meioses in fungi & ordered analysis & unordered analysis CH04: CHROMOSOME MAPPING & RECOMBINATION

17. &key terms on p. 137-8 &questions 1-30 beginning on p. 141 CH04: CHROMOSOME MAPPING & RECOMBINATION

18. &basic concepts & how can bacterial genomes recombine ? & how can viral genomes recombine ? & how do bacterial & viral genomes interact ? &how can we map genomes of these organisms ? &working with microorganisms & growing them &mutants CH05: GENETICS OF BACTERIA & THEIR VIRUSES

19. &conjugation in bacteria & first evidence, F plasmids & F -, F + & Hfr strains & interrupted mating experiments… gene order & high resolution mapping &F’ plasmids &transformation in bacteria & co-transformation mapping CH05: GENETICS OF BACTERIA & THEIR VIRUSES

20. &phage genetics & phage cross &recombination in phage &transduction in bacteria & life cycles & generalized transduction, lytic cycle & specialized transduction, lysogenic cycle & co-transduction mapping CH05: GENETICS OF BACTERIA & THEIR VIRUSES

21. &key terms on p. 176-7 &questions 1-10, 12-32 beginning on p. 179 CH05: GENETICS OF BACTERIA & THEIR VIRUSES