1. Atopic Dermatitis: Immunology and management Dr Amal Kokandi (MBBCh, DDSc, MD)

2. ECZEMA Synonymous with dermatitis Large proportion of skin disease in developed world 10% of population at any one time 40% of population at some time

3. Features of eczema Itchy Erythematous Dry Flaky Oedematous Crusted Vesicles lichenified

4. Diagnosis Clinical No specific laboratory test Family history of atopy is helpful Criteria for research studies: Hanifin & Rajka (1980), United Kingdom Party Criteria (1994)

5. Severity Clinical: Extent, sleep disturbance, Itching, Quality of life. –ADASI (diagramatic), SASSAD, SIS (intensity scoring), etc Biophysical methods: –Eosinophils –IgE (80%) –Immunological markers (sIL-2R, ECP, sCD23, sICAM-1, sELAM-1, sVCAM-1, E selectin, MBP…..)

6. Atopic eczema Endogenous Atopic i.e asthma, hay fever 5% of population 10-15% of all children affected at some time

7. Exacerbating factors Detergents Infection Teething Stress Cat and dog fur ???? House dust mite ???? Food allergen

8. Clinical features Itchy erythematous scaly patches Flexures of knees and elbows Neck Face in infants Exaggerated skin markings Lichenification Nail – pitted ridged

14. complications Bacterial infection Viral infections – warts, molluscum, herpes Keratoconjunctivitis Retarded growth

15. Pathogenesis Not fully understood Genetics Environmental factors: Irritants, aeroallergens, seasonal, hormonal and stress Microbial organisms (Staph Aureus, Malassezia, skin fungi.) and superantigens Modified skin barrier function Deficiency in innate immune system and toll like receptors Specific immunity (biphasic Th1 & Th2)

16. Genetics of atopic eczema 77% & 15% concordance in mono- & dizygotic twins. significant linkage on chromosomes 1q21, 3q21, 3q24-22, 3p26-24 &17q25 polymorphisms in genes important for epidermal differentiation, inflammation (IL-4, IL-12, Fillagrin….)

17. investigations Clinical ??IgE ??RAST

18. Prognosis Most grow out of it! 15% may come back – often very mildly

19. Treatment Patient education Emollients Avoid triggering factors: irritants especially soap Topical steroids Treat infections Sedating antihistamines Second line agents: Calcineurin inhibitors, UV therapy and systemic therapy Immunotherapy: Desensitization

20. creams Cosmetically more acceptable Water based Contain preservatives Soap substitutes

21. ointments Oil based Don’t contain preservative Feel greasy Good for hydrating

22. Topical steroids potency (European) Mild – “hydrocortisone” Moderate – “eumovate” Potent – “betnovate” Very potent – “dermovate”

23. Topical steroid potency (American) Class1 (superpotent) Class2 (potent) Class3 (potent) Class4 (midstrength) Class5 (midstrength) Class6 (mild) Class7 (least potent)

24. FTU Finger tip unit Helps to give estimation of topical steroid amount used To avoid over and under use of steroid

25. FTU

26. 2 FTU = nearly 1 gram Enough for twice size of adult hand –A hand and fingers (front and back) = 1FTU –A foot (all over) + 2FTU –Front of chest and abdomen = 7FTU –Back and buttocks = 7FTU –Face and neck = 2.5 FTU –An entire arm and hand = 4 FTU –An entire leg and foot = 8 FTU Finger tip unit

27. Face Intertriginous areas Children Effect of occlusion infections and combination formulas (with antibiotics and antifungals) Special considerations

28. Topical steroid side effects Perioral dermatitis and rosacea Tachyphylaxis & steroid addiction Infections (tinea incognito, herpes simplex, pityriasis versicolor, scabies……) Adrenal suppression Glucoma and cataract Angina bullosa purpura (hard palate)

29. Topical steroid side effects  Telangiectasia, purpura, epidermal, dermal and subcutaneous atrophy, striae, psuedoscars……  Folliculitis  Allergic reactions  Hypopigmentation  Hypertrichosis  Delayed wound healing  Alteration in skin elasticity & mechanical properties  tinea incognito