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John Heuser Synaptotagmin SNARE Complex VGCC Ca 2+

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Presentation on theme: "John Heuser Synaptotagmin SNARE Complex VGCC Ca 2+"— Presentation transcript:

1

2

3 John Heuser

4

5 Synaptotagmin SNARE Complex VGCC Ca 2+

6 Synaptotagmin SNARE Complex VGCC

7 Ca 2+ Synaptotagmin SNARE Complex VGCC

8

9 Diffusion

10

11 Fick’s First Law of Diffusion

12 distance concentration flux -

13 Fick’s Second Law of Diffusion

14 distance concentration - + flux

15 Fick’s Second Law of Diffusion distance concentration - + flux -

16 Calcium Buffers

17

18 Membrane Calcium Pumps

19 VGCC local calcium global calcium

20 VGCC local calcium global calcium

21

22

23 BAPTA EGTA

24 Squid giant synapse

25 EGTABAPTA

26

27 Fluorescent Calcium Dyes

28 10 μm

29 photolysi s Uncaged Calcium Caged Calcium Calcium Cage

30 The Calyx of Held

31

32

33

34

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