Download presentation
Presentation is loading. Please wait.
1
http://cs273a.stanford.edu [Bejerano Spr06/07] 1 TTh 11:00-12:15 in Clark S361 Profs: Serafim Batzoglou, Gill Bejerano TAs: George Asimenos, Cory McLean
2
http://cs273a.stanford.edu [Bejerano Spr06/07] 2 Lecture 13 Insulators in the Human Genome Discuss Project Co-option
3
http://cs273a.stanford.edu [Bejerano Spr06/07] 3 Insulators: A Reminder
4
http://cs273a.stanford.edu [Bejerano Spr06/07] 4 CTCF [Ohlsson et al., 2001]
5
http://cs273a.stanford.edu [Bejerano Spr06/07] 5 The Glass Ceiling [Ohlsson et al., 2001]
6
http://cs273a.stanford.edu [Bejerano Spr06/07] 6 ChIP-chip reminder
7
http://cs273a.stanford.edu [Bejerano Spr06/07] 7 Breaking the Glass Ceiling [Kim et al., 2007]
8
http://cs273a.stanford.edu [Bejerano Spr06/07] 8 A known locus
9
http://cs273a.stanford.edu [Bejerano Spr06/07] 9 More & less interesting correlations
10
http://cs273a.stanford.edu [Bejerano Spr06/07] 10 Outliers
11
http://cs273a.stanford.edu [Bejerano Spr06/07] 11 Consensus!
12
http://cs273a.stanford.edu [Bejerano Spr06/07] 12 Not all are captured
13
http://cs273a.stanford.edu [Bejerano Spr06/07] 13 From in vitro to in silico [Xie et al., 2007]
14
http://cs273a.stanford.edu [Bejerano Spr06/07] 14
15
http://cs273a.stanford.edu [Bejerano Spr06/07] 15
16
http://cs273a.stanford.edu [Bejerano Spr06/07] 16
17
http://cs273a.stanford.edu [Bejerano Spr06/07] 17
18
http://cs273a.stanford.edu [Bejerano Spr06/07] 18 Genomic Distribution of Ultraconserved Elements exonic non possibly
19
http://cs273a.stanford.edu [Bejerano Spr06/07] 19 Uniquely Abundant in Coelacanth ? x Upto 80%id between Coelacanth instances and some human instances, inc uc.338. 100 diverged copies in a Gigabase 60 highly similar copies in a Megabase
20
http://cs273a.stanford.edu [Bejerano Spr06/07] 20 Repeats / obile Elements ("selfish DNA") Human Genome: 3*10 9 letters 1.5% known function >50% junk
21
http://cs273a.stanford.edu [Bejerano Spr06/07] 21 The LF SINE (for Lobefin Fish / “Living Fossil”) Reconstruction out back target site duplications not similar to any known repeat
22
http://cs273a.stanford.edu [Bejerano Spr06/07] 22 To Be Continued….
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.