1. Burden of COPD Société Belge de Pneumologie Belgische Vereniging voor Pneumologie Danny Galdermans

2. COPD (chronic obstructive pulmonary disease) –chronisch obstructief longlijden, rokerslong –bronchopneumopathie chronique obstructive (BPCO)

3. Definition of COPD airflow limitation (dyspnea) –not fully reversible –usually progressive –associated with abnormal inflammatory response of the lungs to noxious particles or gases (chronic cough and sputum production)

4. SYMPTOMS cough sputum dyspnea EXPOSURE TO RISK FACTORS tobacco occupation indoor/outdoor pollution SPIROMETRY Diagnosis of COPD è è

5. Natural history death disability (1 : nerver or non susceptible smoker; 2 : active susceptible smoker ; 3 : ex-smoker; adapted from Fletcher, 1977 )

6. GOLD guidelines global initiative for chronic obstructive lung disease.

7. Percent Change in Age-Adjusted Death Rates, U.S., 1965-1998 0 0 0.5 1.0 1.5 2.0 2.5 3.0 Proportion of 1965 Rate 1965 - 1998 –59% –64% –35% +163% –7% Coronary Heart Disease Coronary Heart Disease Stroke Other CVD COPD All Other Causes All Other Causes

8. Three-European Country Comparison of COPD Costs

9. Leading Causes of Disability-Adjusted Life Years (DALYs) lost Worldwide, 1990 and 2020 (projected) (adapted from Murray, Science 1999)

10. www.goldcopd.com www.copd.be