1. QUIPPS II 1.Saturate volume of interest RF G SS

2. QUIPPS II 1.Saturate volume of interest 2.Tag (invert) incoming blood RF G SS

3. QUIPPS II 1.Saturate volume of interest 2.Tag incoming blood 3.Kill bottom half of bolus RF G SS

4. QUIPPS II 1.Saturate volume of interest 2.Tag incoming blood 3.Kill bottom half of bolus 4.Wait for the rest to enter VOI 5.Image RF G SS Read-out follows this pulse. Time it takes tagged bolus to reach VOI

5. QUIPPS II Perfusion image = control minus tagged –In tagged image, inverted spins from labeled blood decrease net magnetization