1. Cartilage

2. Functions of Cartilage Tissue Specialized CT in which the firm consistency of the extracellular matrix allows the tissue to bear mechanical stresses without permanent distortion Supports soft tissues. Shock-absorbing because it is resilient. Smooth surface allows sliding against it. Essential for growth, development of bone.

3. Characteristics Chondrocytes (-blasts) –Located in lacunae Extensive extra-cellular matrix –Fibers, ground substance –Collagen, hyaluronic acid, proteoglycans, glycoproteins, elastic (in elastic cartilage) –Macromolecules, water, fibers bind together and give firm, flexible properties to tissue. No blood, nerve supply Low metabolic rate.

4. Perichondrium Dense CT that covers cartilage (except articular cartilage of joints.) Contains blood, nerve supply, lymphatics. Contains collagen fibers, fibroblasts Hyaline cartilage

5. Transition Perichondrium / Cartilage

6. Hyaline Cartilage

7. Chondrocytes in Lacunae

8. CARTILAGE (hyaline) Found at ends of bones, nose, trachea, larynx Bluish white color. Strong, rubbery, flexible tissue.

9. Hyaline Cartilage

10. Growth in the Epiphyseal Plate

11. Epiphyseal Plate (Interstitial Growth) http://web.indstate.edu/thcme/mwking/glycans.html

12. ELASTIC CARTILAGE

13. Similar to hyaline cartilage but has elastic fibers running in all directions in addition to collagen. Found in auricle of ear, walls of external auditory canals, eustachian tubes, epiglottis, larynx Maintains shape, deforms but returns to shape; flexibility of organ; strengths and supports structures. Ear

14. Elastic Cartilage Elastic fibers (elastin) Yellow color

15. Elastic Cartilage (Epiglottis)

16. Fibrocartilage Fibrous Cartilage is a form of connective tissue transitional between dense connective tissue and hyaline cartilage. Chondrocytes may lie singly or in pairs, but most often they form short rows between dense bundles of collagen fibres. In contrast to other cartilage types, collagen type I is dominant in fibrous cartilage. is typically found in relation to joints (forming intra-articular lips, disks and menisci) and is the main component of the intervertebral disks, symphysis pubis. merges imperceptibly into the neighbouring tissues, typically tendons or articular hyaline cartilage. It is difficult to define the perichondrium because of the fibrous appearance of the cartilage and the gradual transition to surrounding tissue types.

17. Fibrocartilage Note the rows of chondrocytes separated by collagen fibers. Fibrocartilage is frequently found in the insertion of tendons on the epiphyseal hyaline cartilage. Picrosirius-hematoxylin stain. Medium magnification.

18. FIBROCARTILAGE Intervertebral disks

19. Fibrocartilage