2. Part Two: Etiology & Pathophysiology of Chronic Kidney Disease By T. Parent Nurse Educator, PHC Community Hemodialysis Units 2015

3. Glomerular disorders

4. Nephrotic & Nephritic syndromes Nephritic syndrome the loss of a lot of blood Nephrotic syndrome the loss of a lot of protein Proteinurea Hypoalbuminemia Edema Hyperlipidemia Hematuria Hypertension Oliguria Azotemia

5. Associated Diseases Minimal change glomerulonep hritis Focal Segmental glomeruloscl erosis Membranous Glomerulonep hritis Post streptococcal glomerulonep hritis IgA Nephropath y Rapidly progressive glomerulone phritis Goodpast ures Vasculitis disorder Wegners granulomat osis Microscop ic polyangiti s Churg Strauss disease Membranoprolif erative Glomerulonephri tis Henoch- Schonlein purpura Diabetic Nephropathy

6. Vascular Diseases Microscopic Polyangiitis Wegener’s BLOOD VESSEL SIZESmall to Medium BLOOD VESSEL TYPEArterioles to venules, And sometimes Arteries and veins GRANULOMATOUS INFLAMMATION NOYES LUNG SYMPTOMSYES 1 GLOMERULONEPHRITISYES RENAL HYPERTENSIONNO MONONEURITIS MULTIPLEX COMMONOCCASIONA L SKIN LESIONSYES 2 GI SYMPTOMSNO EYE SYMPTOMSYES 4 ANCA-POSITIVITY75%65-90% CONSTITUTIONALSYMPT OMS YES 5 NECROTIZING TISSUEYES MICROANEURYSMSRARELY

7. Medullary sponge kidney

8. Neoplasms

9. Interstitial diseases Chronic tubulointerstitial nephritis (CTIN): Acute interstitial nephritis (AIN) allergic drug reactions infections immunologically mediated disorders infections reflux or obstructive nephropathy drugs