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Synthesis of Pyrroles and Indoles Carbonyl condensations (c.f. chapt. 3) - Pyrroles Strategy a; Paal-Knorr synth. Not useful for indoles.

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Presentation on theme: "Synthesis of Pyrroles and Indoles Carbonyl condensations (c.f. chapt. 3) - Pyrroles Strategy a; Paal-Knorr synth. Not useful for indoles."— Presentation transcript:

1 Synthesis of Pyrroles and Indoles Carbonyl condensations (c.f. chapt. 3) - Pyrroles Strategy a; Paal-Knorr synth. Not useful for indoles

2 Strategy b; Knorr synth. Strategy a and b combined; Hantzsch synth.

3 Strategy c

4 Carbonyl condensations (c.f. chapt. 3) - Indoles Strategy b -Reissert synth. - Modified Reissert synth.; Leimbruger-Batcho -Madelung synth.

5 Carbonyl condensations (c.f. chapt. 3) - Indoles Strategy a -Bischler synth. -Gassman synth.

6 Cycloadditions with 1,3-dipoles (c.f. chapt. 3) Reaction with isocyanide

7 Reaction with mesoionic oxido-oxazoliums Reaction with nitrenes

8 Synthesis from aminoalkynes JOC 2003, 7853

9 Miscellaneous indol syntheses Fischer indol synthesis Synthesis from pyrroles

10 Miscellaneous indol syntheses Bartoli synthesis Fürstner synthesis Pd-cat. couplings

11 Bioactive Indoles

12


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