1. Literature Search Strategy Used for the MEDLINE Database Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

2. Flowchart of Article Inclusion *The 36 included articles described 37 studies that included 43 unique cohorts Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

3. Characteristics of Cohort Studies of Metabolic Syndrome and Incident Cardiovascular Disease and Death - Part I Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

4. Characteristics of Cohort Studies of Metabolic Syndrome and Incident Cardiovascular Disease and Death - Part II Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

5. Characteristics of Cohort Studies of Metabolic Syndrome and Incident Cardiovascular Disease and Death - Part III Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

6. RR and 95% CI for Metabolic Syndrome and Incident Cardiovascular Events and Death, by Specific Outcomes Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

7. RR and 95% CI for Metabolic Syndrome and Incident Cardiovascular Events and Death Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

8. RR and 95% CI for Metabolic Syndrome and Incident Cardiovascular Events and Death in Studies That Simultaneously Included Metabolic Syndrome and Some of its Components Into Multivariable Models Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

9. RR and 95% CI for Incident Coronary Heart Disease Events in Patients Without Prevalent Cardiovascular Disease Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

10. Publication Bias and Its Potential Impact Gami AS, et al. J Am Coll Cardiol 2007;49:403-14

11. References Gami AS, et al. J Am Coll Cardiol 2007;49:403-14