1. 23.04.2014 Roberto Carlos Moreno Martín-Bejarano Health and Disease Cancer

2. A) Introduction: Answer the questions of the video. http://www.youtube.com/watch?v=46Xh7OFkkCE “Animated introduction to Cancer Biology”

3. A) Hallmarks of cancer:. From the evolutionist point of view cancer follows the principles of natural selection

4. A) Physiology of cancer. ACCUMULATED MUTATIONS Is the same the iniciating-tumor-cell to the 10th generation cancer cell?

5. A) Hallmarks of cancer: Angiogenesis Why cancer cell spread to other parts of the body?

6. A) Hallmarks of cancer: Anti-angiogenic therapy

7. B) Hallmarks of cancer: Metástasis

8. B) Hallmarks of cancer: Metástasis. DIAGNOSIS

10. Mutacion Expansion Apoptosis Defectos en vias de senescencia o apoptosis Escape de senescencia Nuevas mutaciones Tumor maligno Tumor benigno Senescencia Apoptosis Respuesta antiproliferativa inmediata Lesion Senescencia Stem Cell B) Hallmarks of cancer: Senescencia

11. B) Cancer Stem Cells

12. B) Cancer Stem cells: 2 factors: Genetic mutations

13. B) Cancer Stem cells: 2 factors: Level of mutations + -

14. Kidney for Katie: ROL PLAY

15. D) OUR INVESTIGATION: