2. European Strategy Forum on Research Infrastructures

3. ESFRI roadmap Infrafrontier – animal disease models BBMRI – biobanking
EATRIS – translational research
ECRIN – clinical trials
ELIXIR – bioinformatics
Infrafrontier – animal disease models
INSTRUCT – structural biology
EU-OPENSCREEN – chemical biology
BLS4 – high security labs
Euro-BioImaging - bioimaging
EMBRC – marine biology
First
First
First
roadmap
roadmap
roadmap 35
projects
in 2006
in 2006
in 2006
Update in
Dec
2008
+ 10
projects

4. Grand Challenges - Understand genetic and environmental impact
on human health
- Develop novel strategies for
diagnosis, prevention and therapies

5. Why mouse? Mouse genome fully sequenced
95% similarity of the genes of mice and men
Easy to breed and handle in captivity
Extensive toolbox for manipulating the mouse genome
Child an mouse with the ‘piebald’ trait, a disorder of human development associated with the c-kit gene (Picture from Current Biology 2[3]:161)
Current Biology

6. Mouse models achieve high impact
Why mouse?
Publications on ‘Mouse Models’
Mouse models achieve high impact

7. The challenge Shortage on capacities and access:
Phenotyping (characterising mouse models)
Mouse Clinics
EUMODIC, Infrafrontier
Archiving and Dissemination of mice and data
Repositories
EMMA, Infrafrontier

8. Required capacities Phenotyping Archiving and distribution 1500 p.a.

9. Infrafrontier: two main parts
Phenomefrontier
Archivefrontier
Archivefrontier/EMMA
Systemic
Phenotyping
Archiving /
Distribution
+ emerging centres
+ emerging centres
Access to phenotyping data and mouse models
Access to phenotyping services, data and mouse models

10. Capacity building required!

11. Osteogenesis imperfecta
A group of genetic bone disorders ...
Noted People with OI
Jazz pianist Michel Petrucciani
Actor writer and ethicist Peter Radke...
In the mouse model:
Bisphosphonate treatment
… reverses bone phenotype
… but does not lower mortality

12. The German Mouse Clinic
Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009

13. Mouse model for Osteogenesis imperfecta
- Mutation in collagen I
Bone phenotype
Mineralisation defect
Bone deformity
fractures
Beaded ribs
Reduced Bone mineral content & decreased bone mineral density
Systemic
Lung phenotype
Heart phenotype
Reduced fat mass & increased lean mass
Metabolic alterations

14. Infrafrontier partners
12 European Countries + Canada
Research Institutions + Funding Agencies

15. Infrafrontier partners

16. Smaller Project
Large Project
Infrastructure

17. Very large Project: International Mouse Phenotyping Consortium (IMPC)

18. Infrafrontier and IMPC
Keep in mind:
Infrafrontier is a BMS research infrastructure, NOT a single project
Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects)
State of the art research infrastructures are highly dynamic entities

19. Infrafrontier preparatory phase
Official start: March 2008
36 months until: February 2011
4.5 Mio € funding by the European Commission

20. Infrafrontier implementation

21. Infrafrontier implementation

22. Access to mouse resources and data

23. Operation Costs ES Cell Distribution ? € per line User Fees 500 –700 €
Mouse Archiving
3,500 – 4,400 € per line
Mouse Distribution
1,100 – 2,100 € per line
User Fees
1,100 – 1,700 €
Cohort Breeding
23,000 – 30,000 € per line
Phenotyping
15,000 – 20,000 € per line
User Fees
to be developed

24. New mouse clinics and EMMA nodes
Established facilities
New facilities

25. Integration of national & European funds
Funding Strategy
Integration of national & European funds
National
infrastructure
funds
European Projects
National and
Technology Development
Operation
Personnel
Physical Infrastructure

26. Decentralised funding model
European
Commission MS
Central
Coordination MS MS MS MS MS
MS = Member State

27. Governance Infrafrontier ERIC (Boards)

28. Governance Infrafrontier ERIC (Tasks)

29. More Information ….

30. Resource Sharing Policy
The Rome Agenda:
“Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget.”
“Funding agencies should … ensure appropriate data-sharing plans at the outset of projects …”

31. More Information …. Helmholtz Zentrum München Coordinator:
Prof. Dr. Martin Hrabé de Angelis
Project Office:
Dr. Michael Raess
Dr. Ana de Castro
Helmholtz Zentrum München
Institute of Experimental Genetics
Ingolstädter Landstrasse 1
85764 Neuherberg

33. Scope of Activities

34. Constructing Required Capacities
EMMA Repository
Initial Investment (100 mouse lines):
~ 6,600,000 € for Construction
~ 2,000,000 € for Equipment
Adding capacities for 100 lines
~ 1,300,000 €
Mouse Clinics
Initial Investment (100 mouse lines):
~ 15,000,000 € for Construction
~ 5,000,000 € for Equipment
Adding capacities for 100 lines
~ 6,500,000 €

35. Maintaining Capacities
EMMA Repository
Cryo-Archive (100 mouse lines):
~ 10,000 € per year
Maintaining and Updating Equipment
~ 10% of Purchasing Price per year
Mouse Clinics
Maintaining and Updating Equipment
~ 20% of Purchasing Price per year

36. Infrafrontier project – key objectives
Preparation to meet increasing demands for phenotyping and archiving – capacity building
Developing a business plan based on a sustainable funding concept
Identification of the most suitable legal form
Providing a strategic plan for the construction phase
Reaching a legal agreement between all partners

37. Key deliverables     WP2 – Strategy and Governance
WP3 – Legal Work
WP4 – Financial Work & Funding
Implementation
Preparatory Phase
Strategic Plan
Draft Strategic Plan
Update
WP2  
WP4 Finance 
Business Plan
WP3 Legal Work 
Legal status
MoU