1. ECONOMIA DELLINNOVAZIONE LINNOVAZIONE NELLINDUSTRIA FARMACEUTICA parte I Prof. Stefano Capri Istituto di Economia Università Carlo Cattaneo-LIUC

2. S.Capri - LIUC University

9. Top worldwide pharmaceutical companies

10. S.Capri - LIUC University Revenue drivers R&D pipeline New drugs introduction rate Sales network Relationship network

11. S.Capri - LIUC University Cost drivers R&D Promotion Salesnetwork

12. S.Capri - LIUC University

13. Promotion

14. S.Capri - LIUC University Competitive environment The increase of cost and length of the R&D process The increase of internal competition The advent of generic medicines The expiration of patents The price regulation The advent of personalised medicines

15. S.Capri - LIUC University From Laboratory to Patient: The Complex Pathway of Biopharmaceutical R&D Pharmaceutical Industry Profile 2005 (Washington, DC: PhRMA, March 2005).

16. S.Capri - LIUC University Biopharmaceutical R&D Expenditures and NIH Budget: 1994–2004 Pharmaceutical Industry Profile 2005 (Washington, DC: PhRMA, March 2005).

17. S.Capri - LIUC University The period of market exclusivity between the introduction of a breakthrough medicine and of a competing product is rapidly shrinking

18. S.Capri - LIUC University The expiration of patents Generic erosion

19. S.Capri - LIUC University Price differences among European countries