1. Pain Management Interventions for Hip Fracture Prepared for: Agency for Healthcare Research and Quality (AHRQ) www.ahrq.gov

2.  Introduction to pain management during treatment for hip fracture.  Systematic review methods.  The clinical questions addressed by the comparative effectiveness review (CER).  Results of studies and evidence-based conclusions about effectiveness and harms of pain management interventions.  Gaps in knowledge and future research needs.  What to discuss with patients and their caregivers. Outline of Material Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

3.  The incidence of hip fracture increases with age.  At age 50, the rates are 22.5 per 100,000 for men and 23.9 per 100,000 for women.  At age 80, the rates are 632.2 per 100,000 for men and 1,289.3 per 100,000 for women.  Mortality rates in the 1st year postfracture are high.  25% for women; 37% for men.  Return to prefracture level of function is poor.  25 – 50% of patients have not returned home by 1 year postfracture. Health Impact in the United States of Hip Fracture From Low-Impact Injury Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

4.  Pain following hip fracture has been associated with:  Delirium  Depression  Sleep disturbance  Altered response to treatment for comorbidities  Inadequately managed pain is associated with:  Delayed ambulation  Cardiovascular and pulmonary complications  Delayed transition to less-intensive care settings  Aggravation of comorbidities and mortality risk Consequences of Pain From Hip Fracture Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

5.  May be used preoperatively, intraoperatively, and postoperatively.  May be pharmacological or nonpharmacological.  May combine approaches that disrupt pain in more than one component of pain pathways. This is called “multimodal” pain management. Implementation of Hip Fracture Pain Management (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

6.  Pain management is guided by:  The prior medical status of the patient  Fracture characteristics  Requirements of the treatment plan  The patient population with pain due to hip fracture is predominantly elderly women who have significant and/or multiple comorbidities.  Over age 80: 1,289 per 100,000 women versus 632 per 100,000 men.  Comorbidities can affect both perception of pain and response to pain treatments (both benefits and harms). Implementation of Hip Fracture Pain Management (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

7.  Usual care: Current guidelines recommend systemic analgesia, primarily with nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, as the 1st-line approach for management of moderate to severe pain in elderly patients in general.  Complications of opioids include:  Alterations in mental status  Nausea and vomiting  Respiratory depression  Tolerance  Which alternative or adjunctive methods are safe and effective options that can be used within the clinical circumstances of older adults with hip fracture? Implementation of Hip Fracture Pain Management (3) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

8.  Topics are nominated through a public process, which includes submissions from health care professionals, professional organizations, the private sector, policymakers, members of the public, and others.  A systematic review of all relevant clinical studies is conducted by independent researchers, funded by AHRQ, to synthesize the evidence in a report summarizing what is known and not known about the select clinical issue. The research questions and the results of the report are subject to expert input, peer review, and public comment.  The results of these reviews are summarized into Clinician Guides and Consumer Guides for use in decisionmaking and in discussions with patients. The Guides and the full report, with references for included and excluded studies, are available at www.effectivehealthcare.ahrq.gov. Agency for Healthcare Research and Quality (AHRQ) Comparative Effectiveness Review (CER) Development Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

9.  The strength of evidence was classified into four broad categories: Rating the Strength of Evidence From the CER Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

10.  In older adults, what is the effectiveness of pain management interventions for controlling acute (up to 30 days postfracture) and chronic pain (up to 1 year postfracture), compared to usual care or other interventions?  What is the effect of pain management interventions on outcomes other than pain (up to 1 year postfracture), compared to usual care or other interventions?  For example: mortality, mental status Clinical Questions Addressed by the CER (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

11.  What are the nature and frequency of adverse effects associated with pain management interventions, up to 1 year postfracture?  Myocardial infarction, renal failure, and stroke  How do patient subpopulation characteristics affect effectiveness and safety? Clinical Questions Addressed by the CER (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

12.  Systemic Analgesia  Both narcotic (opioids) and non-narcotic (NSAIDs, acetaminophen) medications are typical in “usual care.”  Nerve Blocks (regional blocks)  Injection of anesthetics into nerve bundles prevents the generation and conduction of nerve impulses to the spinal cord and brain.  Traction  A traditional approach for the population of patients with hip fracture.  Preoperative skin or skeletal traction.  Goal is to stabilize the fractured leg, to reduce pain, and to improve fracture reduction. Pain Management Interventions Included in This CER (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

13.  Anesthesia  Neuraxial: spinal and epidural  Injection of an anesthetic into the epidural or subarachnoid space in the spinal column  Transcutaneous Electrical Neurostimulation (TENS)  Applies electrical energy to peripheral nerves, to reduce the perception of pain  Uses varying amplitudes and frequencies, depending on indication  Rehabilitation  Part of standard postoperative care  Goal is to increase mobility and reduce pain by improving muscle strength and range of motion  Participation can be limited by delirium and degree of pain experienced by the patient Pain Management Interventions Examined in this CER (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

14.  Complementary and Alternative Medicine (CAM)  Systems, practices, and products that are not part of conventional medicine, such as:  Acupressure: applying pressure at body sites away from the pain locale.  Jacobson relaxation technique: alternating between contracting and relaxing muscles.  Multimodal Pain Management  The use of multiple strategies as part of the clinical pathway.  Intent is to decrease pain to a greater extent than with one intervention alone. Pain Management Interventions Examined in this CER (3) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

15.  Acute and Chronic Pain Intensity  Overall pain  Pain on movement  Pain at rest  Most research has focused on acute pain, the emotional and sensory response to injury, which lasts for the duration of injury and healing.  For hip fracture studies, the duration for acute pain is defined as occurring up to 30 days postfracture. Clinically Significant Outcomes of Interest Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

16.  The patient’s self-report of pain is the standard for evaluating the character and intensity of pain.  There is no consensus about the exact cutoff for determining a clinically significant reduction in pain.  Two methods commonly used to assess the intensity of pain:  Visual analog scale (VAS):  On a 10-cm line, “where the far left is no pain and the far right end is the worst pain ever, point to how your pain feels.”  Numerical scale:  For example, “On a scale of 0 – 10, where 0 is no pain and 10 is the worst pain possible, how would you rate your pain?”  Numerical scales show a linear correlation with VAS results. Measuring Pain in Clinical Studies (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

17.  For the evidence presented here, pain measurements were evaluated as differences between intervention and comparator VAS means as measured after treatment.  Test intervention VAS mean − control intervention VAS mean = VAS mean difference.  The values are reported as centimeters (cm) difference.  For example, a mean difference of -1.0 expresses an additional 1-cm shift of the indicated point on the VAS toward “less pain,” achieved by the test intervention when compared with the control intervention.  Absolute change from baseline for test and control interventions is not reported here. Measuring Pain in Clinical Studies (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

18.  The evidence about these outcomes and events was evaluated:  Clinically significant outcomes:  30-day mortality rate  Mental status (delirium)  Quality of life  Serious Adverse Events:  Stroke  Myocardial infarction  Renal failure Other Clinically Significant Outcomes and Adverse Events Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

19.  Population: Elderly patients experiencing pain from nonpathological, low-impact injury hip fractures.  Interventions: Pain management methods, including systemic analgesia, neuraxial anesthesia, nerve blocks, traction, TENS, rehabilitation, complementary and alternative methods, and multimodal approaches.  Comparators: usual care (non-narcotic and opioid), and/or other interventions.  Outcomes: pain intensity, mental status, 30-day mortality, serious adverse events (stroke, myocardial infarction, renal failure).  The evidence about only these key outcomes was scored for strength of evidence.  Timing: acute care, within 30 days of fracture.  Setting: acute care. Summary of Study Characteristics Evaluated in the Effectiveness Review: PICOTS Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

20. Controlled Trials of Pain Interventions Examined in the Effectiveness Review Category of InterventionPossible Timing of Use StudiesTiming Used in Studies Systemic analgesiaPreop, intraop, and postop3Preop and postop Anesthesia (spinal and epidural) Preop, intraop, and postop30Intraop Nerve blocksPreop, intraop, and postop32Preop, intraop, and postop TractionPreop11Preop Transcutaneous Electrical Neurostimulation (TENS) Preop and postop2 Acupressure; relaxation techniques Preop and postop2Preop RehabilitationPostop1 Multimodal Pain Management Preop, intraop, and postop2Preop and postop Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm. Intraop = intraoperative; postop = postoperative; preop = preoperative.

21.  Of the 71 controlled trials of pain management interventions reviewed, only 37 directly measured effects on pain. Others measured secondary outcomes (e.g., mental status). Controlled Trials Reporting Effectiveness for Acute Pain Category of InterventionNumber of Controlled Trials and Timing Systemic analgesia 1 preoperative; 2 postoperative Anesthesia (spinal and epidural)5 intraoperative Nerve blocks10 preoperative; 4 intraoperative; 4 postoperative Traction 8 skin; 1 skin vs. skeletal; 1 skeletal; all preoperative Transcutaneous Electrical Neurostimulation (TENS) 1 preoperative; 1 postoperative Acupressure; relaxation techniques 2 preoperative Rehabilitation1 postoperative Multimodal pain management0 Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

22.  No studies compared effectiveness, benefits, and harms of the systemic analgesics commonly used in pain management (non- narcotic and opioid) for elderly patients with hip fractures.  The evidence is insufficient to make any conclusions about the effectiveness or safety of these interventions or other systemic analgesics in elderly patients with hip fractures. Effectiveness of Systemic Analgesics for Acute Pain: Trials, Results, and Conclusions Intervention 1Intervention 2(No. of Trials) ResultStrength of Evidence Intravenous parecoxibIntramuscular diclofenac, with or without meperidine (1) No clinically important difference Insufficient Intrathecal isotonic clonidine Intrathecal hypertonic clonidine (1) No statistically significant difference Insufficient Lysine clonixinateMetamizole(1) No statistically significant difference Insufficient Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

23.  The evidence is insufficient to understand the effectiveness against acute pain of differing doses, modes of administration, and the addition of opioids to the anesthetic injection. Effectiveness of Anesthesia on Acute Pain: Trials, Results, and Conclusions Intervention (Timing)Comparators No. of Trials Strength of Evidence Spinal Anesthesia (intraoperative) Versus general anesthesia1Insufficient Spinal or Epidural Anesthesia (intraoperative) With versus without adding opioids to the injection 3Insufficient Differing doses0No data Single versus continuous modes0No data Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

24. Effectiveness of Nerve Block on Acute Pain (Overall Pain): Trials and Results Intervention (Timing)Comparator No. of Trials (Treated, Control) Mean Difference in Pain: Intensity, VAS, cm* (95% CI) Strength of Evidence Combined obturator + femoral (postop) Opioids2 (80, 55)-2.68† (-3.22, -2.14) Moderate (for the combined literature) 3-in-1 (postop)Morphine, Acetaminophen 2 (41, 61)-0.05 (-0.58, 0.48) -0.08 (-0.70, 0.54) 3-in-1 (preop)Morphine1 (24, 26)-1.43 (-2.06, -0.80) Fascia iliaca (postop) Placebo, Opioids1 (30,30)-4.06 (-4.97, -3.16) Fascia iliaca (preop) Placebo, NSAIDS, Meperidine 2 (194, 167)-0.06 (-0.26, 0.38) -0.44 (-0.72, -0.16) Femoral (preop)Opioids, Morphine 3 (47, 62)-1.01† (-1.46, -0.57) Psoas compartment (preop)Meperidine1 (20, 20)-1.05 (-1.72, -0.39) Psoas; Posterior lumbar plexus; Combined lumbar + sacral (intraop) Spinal anesthesia3 (55, 54)-0.35† (-1.10, 0.39)Low *Centimeters difference; † Meta-estimate. Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

25.  In general, nerve blocks provide greater relief from the acute pain of hip fracture than usual care alone.  Strength of Evidence = Moderate  Nerve blocks used intraoperatively may be as effective as epidural and spinal anesthesia for relief of acute pain.  Strength of Evidence = Low Effectiveness of Nerve Block on Acute Pain: Conclusions Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

26.  Meta-analysis indicates that skin traction does not provide more relief from acute pain than standard care.  The difference between treated and control groups for reported intensity of pain is neither clinically important nor statistically significant.  Strength of Evidence = Low  In one trial, skeletal traction exhibited no statistically significant difference in pain relief when compared with skin traction. Effectiveness of Skin Traction on Acute Pain: Trials, Results, and Conclusions Intervention (Timing)Comparators No. of Studies (Treated, Control) Mean Difference in Pain Intensity, VAS, cm* (95% CI) Strength of Evidence Skin Traction (preoperative) Pillow and standard care (opioid and NSAID analgesics) 8 (498, 594)0.20 (-0.24, 0.65)Low Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

27.  The meta-estimate indicates that TENS may relieve pain more than a sham control with standard care in both preoperative and postoperative use.  However, the evidence is insufficient to form a conclusion about potential benefits to assist in decisionmaking. Effectiveness of TENS on Acute Pain: Trials, Results, and Conclusions Intervention (Timing)Comparators Number of Studies (Treated, Control) Mean Difference in Pain Intensity, VAS, cm* (95% CI) Strength of Evidence TENS (preoperative and postoperative) Sham control and standard care (opioid and NSAID analgesics) 2 (60, 63)-2.79 (-4.95, -0.64)Insufficient Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

28.  Acupressure and the Jacobson relaxation technique may contribute to pain reduction over that from standard care alone, but the evidence is insufficient to permit a conclusion about the extent of potential benefits. Effectiveness of Complementary and Alternative Medicine Techniques for Acute Pain: Trials, Results, and Conclusions Intervention (Timing)Comparators No, of Studies (Treated, Control) Mean Difference in Pain Intensity, VAS, cm* (95% CI) Strength of Evidence Acupressure (preoperative) Sham control and standard care (opioid and NSAID analgesics) 1 (18, 20)-3.01 (-4.53, -1.49)Insufficient Jacobson Relaxation Technique (preoperative) Standard care (opioid and NSAID analgesics) 1 (30, 30)-1.1 (-1.43, -0.77)Insufficient Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

29.  Stretching and strengthening exercises reduced acute pain (back pain) more than standard care alone, but the evidence is insufficient to permit a conclusion about benefits. Effectiveness of Rehabilitation on Acute Pain: Trials, Results, and Conclusions Intervention (Timing)Comparators Number of Studies (Treated, Control) Mean Difference in Pain Intensity, VAS, cm* (95% CI) Strength of Evidence Rehabilitation Exercises (postoperative) Standard care (opioid and NSAID analgesics) 1 (18, 19)-1.39 (-2.27, -0.51)Insufficient Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

30.  Clinically important outcomes that may show differences between pain-control methods include:  Mortality rate (at 30 days)  Mental status (delirium)  Health-related quality of life Evidence About Effectiveness for Other Outcomes Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

31.  The evidence is insufficient to estimate the effect on mortality rate, mental status, or health-related quality of life of these interventions: Effectiveness of Pain Management Interventions on Other Important Outcomes InterventionOutcomesNumber of Studies Systemic analgesicsMental status1 study Complementary and Alternative Medicine No data Multimodal Pain Management Mortality Mental status 1 study 2 studies RehabilitationNo data TractionMortality1 study TENSHealth-related quality of life1 study Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

32. InterventionComparatorOutcome No. of Studies (Treated, Control) Result: Odds Ratio (95% CI) Strength of Evidence Continuous spinal anesthesia Single administration spinal 30-Day mortality mate 3 (81, 82)OR = 0.46 (0.07, 3.02) Low Mental status (delirium) 2 (67, 67)OR = 1.27 (0.32, 4.99) Low Effectiveness of Anesthesia on Other Important Outcomes  Continuous and single-dose modes of spinal anesthesia do not differ in effects on the 30-day mortality rate or mental status.  For all other comparisons of doses, modes of administration, and the addition of opioids to the injection, the evidence is insufficient to determine an estimate of the effect. Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

33. Outcome No. of Studies (Treated, Control) Result: Odds Ratio (95% CI) Strength of Evidence 30-Day Mortality Rate4 RCTs (114, 114) OR = 0.28 (0.07, 1.12) Low Mental Status (occurrence of delirium) 4 RCTs (242, 219) OR = 0.36 (0.17, 0.74) Moderate Mental Status (occurrence of delirium) 2 Cohort studies (227, 407) OR = 0.24 (0.08, 0.72 ) Moderate Effectiveness of Nerve Block on Other Important Outcomes  In all studies, nerve blocks were compared with standard care alone.  Nerve blocks do not affect 30-day mortality rates.  Nerve blocks do reduce the incidence of delirium.  NNT (number needed to be treated to have one additional patient benefit, when compared with usual care,) from randomized controlled trial (RCT) data = 9. Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

34.  Nerve Blocks  Reduce the intensity of acute pain.  Strength of Evidence = Moderate  Can be as effective as spinal anesthesia for relief of acute pain.  Strength of Evidence = Low  Reduce the likelihood of delirium (NNT = 9).  Strength of Evidence = Moderate  Do not affect mortality rates.  Strength of Evidence = Low Summary of Benefits (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

35.  Spinal Anesthesia  Continuous versus single-dose modes do not differ in effect on mortality rates or incidence of delirium.  Strength of Evidence = Low  The evidence is insufficient to understand the effectiveness and benefits of differing doses, modes of administration, and the addition of opioids to the anesthetic injection.  Skin traction  Does not reduce the intensity of acute pain.  Strength of Evidence = Low Summary of Benefits (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

36.  Rehabilitation, Acupressure, Jacobson Relaxation Technique, and TENS:  The current evidence indicates that these modalities show some promise for pain relief, but the data are too limited to permit conclusions about the benefits or harms. Summary of Benefits (3) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

37.  Evidence about clinically significant, serious adverse events influenced by pain interventions was examined for the effectiveness review.  These events are:  Stroke  Myocardial infarction  Renal failure Adverse Events Influenced by Pain Management Interventions Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

38. Category of Intervention No. of Studies Timing Used in Studies Evidence Strength for Serious Adverse Events Systemic analgesia2Postop NA Anesthesia20Intraop Insufficient Nerve blocks22Preop, intraop, and postop Insufficient Traction (Skin)8Preop NA Transcutaneous Electrical Neurostimulation (TENS) 0Preop and postop NA Acupressure; relaxation techniques (Complementary and Alternative Medicine) 0Preop NA Rehabilitation0Postop Insufficient Multimodal pain management1Preop and postop Insufficient Studies Reporting Evidence About Adverse Events Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

39.  Overall, adverse event rates were similar in both treated and control groups, but studies were not powered to identify statistically significant differences.  Myocardial infarction, stroke, and renal failure were either rarely reported or no significant differences were found between groups.  The evidence is insufficient to understand the association of pain management interventions with clinically significant, serious adverse events that occur in elderly patients with hip fracture. Adverse Events Influenced by Pain Management Interventions Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

40.  Response to pain management may be affected by patient subpopulation characteristics, including:  Age  Sex  Comorbidities  Prefracture functional status Influence of Subpopulation Characteristics on Effectiveness and Safety (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

41.  Only two studies of nerve blocks were performed with consideration of subpopulation characteristics.  One study in individuals with Preopexisting heart disease.  One study in individuals who were independent before their hip fracture.  No other studies were designed to determine effects of patient characteristics on outcomes.  The evidence is insufficient to understand the influences of subpopulation characteristics on effectiveness, benefits, or adverse events. Influence of Subpopulation Characteristics on Effectiveness and Safety (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

42.  Overall, there is limited evidence about the comparative effectiveness, benefits, and harms of pain management interventions used for elderly patients with hip fracture.  Evidence of moderate strength supports the findings that nerve blocks reduce pain and the incidence of delirium when compared with usual care alone.  Evidence of low strength supports the finding that preoperative traction does not improve relief from acute pain.  For all modalities, including those most commonly used (acetaminophen, NSAIDs, and opioids), the evidence is inadequate to estimate harms and the incidence of common adverse events in elderly patients with hip fracture. Conclusions About Benefits and Adverse Events Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

43.  Few studies of pain management interventions have been performed that specifically address effectiveness, benefits, and harms in elderly patients with hip fracture.  There are no studies that compare the effectiveness and safety of the systemic opioid and NSAID analgesics that are used for elderly patients with hip fracture.  There is no evidence about the effectiveness of multimodal approaches for acute pain relief, and the evidence is insufficient to understand the influence of the pain-relief approach on adverse events. Knowledge Gaps and Future Research Needs (1) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

44.  How rehabilitation techniques may affect either acute or chronic pain is unexplored.  Knowledge is very limited about the benefits and adverse events associated with pain management approaches in the long term (beyond 30 days).  Applicability of current studies is limited, as patients in institutional settings and those with cognitive impairment were rarely represented. Knowledge Gaps and Future Research Needs (2) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

45.  To improve evidence quality and reduce bias, future research should use blinded outcome assessors, validated and standardized outcome-assessment tools, adequate concealment of allocation to an intervention (where applicable), and appropriate handling of missing data.  Multicenter research studies are needed that are large enough for statistical analysis of subgroups (by age, gender, comorbidities, or prefracture functional status) and for detection of adverse effects. Knowledge Gaps and Future Research Needs (3) Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.

46.  Managing pain during the period from injury through rehabilitation is important for advancing return to function and quality of life.  There are options for pain management that may be suitable for patients with a variety of comorbidities.  There is limited evidence about the benefits and harms of pain-control interventions when they are used for elderly patients with hip fractures. What To Discuss With Your Patients and Their Caregivers Abou-Setta AM, Beaupre LA, Jones CA, et al. AHRQ Comparative Effectiveness Review No. 30. Available at: http://effectivehealthcare.ahrq.gov/hippain.cfm.