1. Periph Periph er a a l Nerve Gen Gen e Therapy
Innovative solutions for neurological disorders

2. How NET Drugs Treat Pain
Traditional Pain Drugs
NET Pain Drugs
Dry mouth
Muscle aches & weakness
GI problems
Constipation
Blurred vision
Dizziness, drowsiness, cognitive changes
Swollen hands & feet
No systemic side effects
Pain signal to brain
Daily systemic
oral drug
Mild Pain Relief
Better Pain Relief
Injury
Monthly
skin
delivery
Drug spreads throughout the body
Net drug localized to treated nerves
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3. How NET Drugs Treat Neuropathy
Chemotherapy alone
With NET CIPN Drug
Chemotherapy course
Chemotherapy course
Full course
Increased survival
Reduced course
Reduced survival
Pain, dysethesia,
paresthesia
Prophylactic skin delivery
No damage to nerve fibers
Damage to nerve fibers
Dose-dependent chemotherapy induced peripheral neuropathy (CIPN)
Peripheral nerves protected