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Long-Term Outcomes and Modes of Failure of the Ross Operation in Patients with Aortic Insufficiency Joel Price MD, MPH, Laurent De Kerchove MD, David Glineur.

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Presentation on theme: "Long-Term Outcomes and Modes of Failure of the Ross Operation in Patients with Aortic Insufficiency Joel Price MD, MPH, Laurent De Kerchove MD, David Glineur."— Presentation transcript:

1 Long-Term Outcomes and Modes of Failure of the Ross Operation in Patients with Aortic Insufficiency
Joel Price MD, MPH, Laurent De Kerchove MD, David Glineur MD, PhD, Jean Rubay MD, and Gebrine El Khoury MD Department of Cardiovascular and Thoracic Surgery Cliniques St. Luc Brussels, Belgium

2 Background Long-term durability of the Ross operation when performed for isolated aortic insufficiency has been questioned. Especially important in the setting of a regurgitant bicuspid aortic valve bicuspid aortopathy involves the pulmonary trunk

3 Methods Isolated AI: AI (≥ 3+), absence of significant stenosis (mean gradient <30mmHg, AVA >1.5cm2) Review of institutional database revealed 68 patients underwent Ross operation for AI Mean follow-up 11.2 y, max follow-up 18.8y Complete as of March 2011 Statistical Anlysis: Kaplan-Meier, Log-rank and time-to-event

4 Outcomes Long-term survival and Cardiac survial
Recurrent significant AI (autograft regurgitation) Reoperation Valve-related events: Endocarditis, hemorrhage, thrombo-embolism Sub group analysis: Bicuspid vs tricuspid

5 Patient Charactersitics
Age 37.8 ± 9.8 Bicuspid Valve 55.9% NYHA Class 2.1± 0.8 Male 83.8% EF > 50% 92.8% Associated Procedure 11.9%

6 Long-Term Outcomes Outcome 5 Yrs 10 yrs Overall Survival 95%±3%
Cardiac Survival 100% Freedom from Recurrent AI 91%±4% 88%±5% Freedom from Reoperation 89%±4% Freedom from VRE

7 Reoperations Time Post Op (months) Site Indication Corrective Surgery
119 Aortic Valve AI + Dilation Mechanical Bentall 174 Dilation AVSRR 142 64 AI AV Repair 107 53 48 AI + Infective Endocarditis Stentless Root Replacement 178 151 Dilation + Homograft Stenosis AVSRR + Pulmonary Homograft 31 Mechanical AVR AVSRR = Aortic Valve Sparring Root Replacement, AV = Aortic Valve, AVR = Aortic Valve Replacement

8 Survival: Bicuspid vs Tricuspid

9 Recurrent AI: Bicuspid vs Tricuspid

10 Reoperation: Bicuspid vs Tricuspid

11 VRE: Bicuspid vs Tricuspid

12 Conclusions Ross operation for isolated AI was associated with excellent survival and freedom from recurrent AI, reoperation and valve-related events Bicuspid and tricuspid valves have equivalent outcomes Main mechanisms of failure are AI and autograft dilation


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